Sorted by Authors

Publications - Sorted by Authors

• Garcia Moreno S, Limani F, Ludwig I, Gilbert C, Pifl C, Hnasko T, Steinkellner T (2024) Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration Exp. Neurol., 382: 114959

• Pifl C, Reither H, Attems J, Zecca L (2023) Dopamine and vesicular monoamine transport loss supports incidental Lewy body disease as preclinical idiopathic Parkinson npj Parkinson's Disease, Jun 15;9(1):89
• Bhat S, El-Kasaby A, Kasture A, Boytsov D, Reichelt J, Hummel T, Sucic S, Pifl C, Freissmuth M, Sandtner W (2023) A mechanism of uncompetitive inhibition of the serotonin transporter eLife, 12/e82641
• Dorninger F, Kiss A, Rothauer P, Stiglbauer-Tscholakoff A, Kummer S, Fallatah W, Perera-Gonzalez M, Hamza O, König T, Bober M, Cavallé-Garrido T, Braverman N, Forss-Petter S, Pifl C, Bauer J, Bittner R, Helbich T, Podesser B, Todt H, Berger J (2023) Overlapping and Distinct Features of Cardiac Pathology in Inherited Human and Murine Ether Lipid Deficiency Int J Mol Sci, 24 (3): 1884

• Fallatah W, Cui W, Di Pietro E, Carter G, Pounder B, Dorninger F, Pifl C, Moser A, Berger J, Braverman N (2022) A Pex7 Deficient Mouse Series Correlates Biochemical and Neurobehavioral Markers to Genotype Severity—Implications for the Disease Spectrum of Rhizomelic Chondrodysplasia Punctata Type 1 Front Cell Dev Biol, 10
• Fallatah W, Cui W, Di Pietro E, Carter G, Pounder B, Dorninger F, Pifl C, Moser A, Berger J, Braverman N (2022) A Pex7 Deficient Mouse Series Correlates Biochemical and Neurobehavioral Markers to Genotype Severity—Implications for the Disease Spectrum of Rhizomelic Chondrodysplasia Punctata Type 1 Front Cell Dev Biol, 10
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• da Silva SR, Kalaba P, Fabisikova A, Zehl M, Dragacevic V, Ribeiro dos Anjos L, Neill PJ, Wieder M, Prado-Roller A, Gajic N, Palaretti V, da Silva GVJ, Pifl C, Lubec G, Gonzalez ERP (2021) Synthesis and dopamine receptor binding of dihydrexidine and SKF 38393 catecholamine-based analogues Amino Acids, Published Online: 29 November 2021
• Lubec J, Kalaba P, Hussein A, Feyissa D, Kotob M, Mahmmoud R, Wieder O, Garon A, Sagheddu C, Ilic M, Dragačević V, Cybulska-Klosowicz A, Zehl M, Wackerlig J, Sartori S, Ebner K, Kouhnavardi S, Roller A, Gajic N, Pistis M, Singewald N, Leban J, Korz V, Malikovic J, Plasenzotti R, Sitte H, Monje F, Langer T, Urban E, Pifl C, Lubec G (2021) Reinstatement of synaptic plasticity in the aging brain through specific dopamine transporter inhibition Mol Psychiatry,
• Bhat S, Niello M, Schicker K, Pifl C, Sitte H, Freissmuth M, Sandtner W (2021) Handling of intracellular K+ determines voltage dependence of plasmalemmal monoamine transporter function eLife, 10

• Zecca L, Pifl C, Fahn S, Sulzer D, Fariello R (2021) Oleh Hornykiewicz, a giant in the understanding and treatment of Parkinson disease npj Parkinson's Disease, 7 (1)

• Pifl C, Sitte H (2020) A Tribute to Oleh Hornykiewicz (1926–2020) Trends Pharmacol Sci, 41 (8): 499-501

• Kalaba P, Ilić M, Aher N, Dragačević V, Wieder M, Zehl M, Wackerlig J, Beyl S, Sartori S, Ebner K, Roller A, Lukic N, Beryozkina T, Gonzalez E, Neill P, Khan J, Bakulev V, Leban J, Hering S, Pifl C, Singewald N, Lubec J, Urban E, Sitte H, Langer T, Lubec G (2019) Structure–Activity Relationships of Novel Thiazole-Based Modafinil Analogues Acting at Monoamine Transporters J Med Chem, 63 (1): 391-417
• Hörtnagl H, Pifl C, Hörtnagl E, Reiner A, Sperk G (2019) Distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the human brain J Neurochem, 152 (6): 650-662
• Korchynska S, Krassnitzer M, Malenczyk K, Prasad R, Tretiakov E, Rehman S, Cinquina V, Gernedl V, Farlik M, Petersen J, Hannes S, Schachenhofer J, Reisinger S, Zambon A, Asplund O, Artner I, Keimpema E, Lubec G, Mulder J, Bock C, Pollak D, Romanov R, Pifl C, Groop L, Hökfelt T, Harkany T (2019) Life‐long impairment of glucose homeostasis upon prenatal exposure to psychostimulants EMBO J., 39 (1)
• Dorninger F, König T, Scholze P, Berger M, Zeitler G, Wiesinger C, Gundacker A, Pollak D, Huck S, Just W, Forss-Petter S, Pifl C, Berger J (2019) Disturbed Neurotransmitter Homeostasis in Ether Lipid Deficiency Hum Mol Genet, 28(12): 2046-2061

• Pifl C (2019) The Time Delay Between In Vivo Imaging and Postmortem Data Poses a Caveat on “No Link” Findings Movement Disorders, 34: 1579-1580

• Alpár A, Zahola P, Hanics J, Hevesi Z, Korchynska S, Benevento M, Pifl C, Zachar G, Perugini J, Severi I, Leitgeb P, Bakker J, Miklosi AG, Tretiakov E, Keimpema E, Arque G, Tasan RO, Sperk G, Malenczyk K, Máté Z, Erdélyi F, Szabó G, Lubec G, Palkovits M, Giordano A, Hökfelt TG, Romanov RA, Horvath TL, Harkany T. (2018) Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress EMBO J., 37: e100087
• Maier J, Mayer FP, Luethi D, Holy M, Jaentsch K, Reither H, Hirtler L, Hoener MC, Liechti ME, Pifl C, Brandt SD, Sitte HH (2018) The psychostimulant (±)-cis-4,4′-dimethylaminorex (4,4′-DMAR) interacts with human plasmalemmal and vesicular monoamine transporters Neuropharmacology, 138: 282-291

• Pifl C, Reither H, Lopez-Gonzalez del Rey N, Cavada C, Obeso JA, Blesa J (2017) Early paradoxical increase of dopamine: A neurochemical study of olfactory bulb in asymptomatic and symptomatic MPTP treated monkeys Front Neuroanat, 11: 46
• Rivetti di Val Cervo P, Romanov RA, Spigolon G, Masini D, Martín-Montañez E, Toledo EM, La Manno G, Feyder M, Pifl C, Ng YH, Sánchez SP, Linnarsson S, Wernig M, Harkany T, Fisone G, Arenas E (2017) Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model Nat Biotechnol, 35: 444-452

• Pifl C (2016) Problems with traffic ahead: Synaptic vesicles in Parkinson's disease Movement Disorders, 31: 1480
• Sitte HH, Pifl C, Rajput AH, Hörtnagl H, Tong J, Lloyd GK, Kish SJ, Hornykiewicz O (2016) Dopamine and noradrenaline, but not serotonin, in the human claustrum are greatly reduced in patients with Parkinson's disease: possible functional implications Eur J Neurosci, 45: 192-197
• Peneder T, Bauer J, Pifl C (2016) Apoptosis-inducing factor in nigral dopamine neurons: Higher levels in primates than in mice Movement Disorders, 31: 1729-1733

• Pifl C, Reither H, Hornykiewicz O (2015) The profile of mephedrone on human monoamine transporters differs from 3,4-methylenedioxymethamphetamine primarily by lower potency at the vesicular monoamine transporter Eur J Pharmacol, 755: 119-126
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• Pifl C, Rajput A, Reither H, Blesa J, Cavada C, Obeso JA, Rajput AH, Hornykiewicz O (2014) Is Parkinson's Disease a Vesicular Dopamine Storage Disorder? Evidence from a Study in Isolated Synaptic Vesicles of Human and Nonhuman Primate Striatum J Neurosci, 24: 8210-8218

• Pifl C, Hornykiewicz O, Blesa J, Adanez R, Cavada C, Obeso JA (2013) Reduced noradrenaline, but not dopamine and serotonin in motor thalamus of the MPTP primate: relation to severity of Parkinsonism J Neurochem, 125: 657-662

• Pifl C, Stephen J, Kish SJ, Hornykiewicz O (2012) Thalamic noradrenaline in Parkinson's disease: Deficits suggest role in motor and non-motor symptoms Movement Disorders, 27: 1618-1624
• J. Blesa, C. Pifl, M.A. Sánchez-González, C. Juri, M.A. García-Cabezas, R. Adánez, E. Iglesias, M. Collantes, I. Peñuelas, J.J. Sánchez-Hernández, M.C. Rodríguez-Oroz, C. Avendaño, O. Hornykiewicz et (2012) The nigrostriatal system in the presymptomatic and symptomatic stages in the MPTP monkey model: A PET, histological and biochemical study Neurobiol Dis, 48: 79-91
• Sperk G, Wieselthaler-Hölzl A, Pirker S, Tasan R, Strasser SS, Drexe M, Pifl C, Marschalek J, Ortler M, Trinka E, Haitmair-Wietzorrek K, Ciofi P, Feucht M, Baumgartner C, Czech T (2012) Glutamate decarboxylase67 is expressed in hippocampal mossy fibers of temporal lobe epilepsy patients Hippocampus, 22: 590-603
• Sommerauer C, Rebernik P, Reither H, Nanoff C, Pifl C (2012) The noradrenaline transporter as site of action for the anti-Parkinson drug amantadine. Neuropharmacology, 62 (4): 1708-1716
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• Neuhaus W, Freidl M, Szkokan P, Berger M L, Wirth M, Winkler J, Gabor F, Pifl C, Noe CR (2011) Effects of NMDA receptor modulators on a blood-brain barrier in vitro model Brain Res, 1394: 49-61
• Peneder TM, Scholze P, Berger ML, Reither H, Heinze G, Bertl J, Bauer J, Richfield EK, Hornykiewicz O, Pifl C (2011) Chronic exposure to manganese decreases striatal dopamine turnover in human alpha-synuclein transgenic mice Neuroscience, 180: 280-292

• Hanada R, Leibbrandt A, Hanada T, Kitaoka S, Furuyashiki T, Fujihara H, Trichereau J, Paolino M, Qadri F, Plehm R, Klaere S, Komnenovic V, Mimata H, Pifl C, Penninger J et al (2009) Central control of fever and female body temperature by RANKL/RANK Nature, 462: 505-509
• Pifl C, Wolf A, Rebernik P, Reither H, Berger M L (2009) Zinc regulates the dopamine transporter in a membrane potential and chloride dependent manner Neuropharmacology, 56: 531-540
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• Rajput A.H., Sitte H.H., Rajput A., Fenton M.E., Pifl C., Hornykiewicz O. (2008) Globus pallidus dopamine and Parkinson motor subtypes. Neurology, 70: 1403-1410
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• Nanoff C, Pifl C (2008) Neurotransmitter transporters. In: , Encyclopedia of Molecular Pharmacology Springer Berlin Heidelberg: 836-842

• Pifl C, Hornykiewicz O (2006) Dopamine turnover is upregulated in the caudate/putamen of asymptomatic MPTP treated rhesus monkeys. Neurochem Internat, 49: 519-524

• Pifl C, Sperk G (2006) Current topics in brain dopamine research: a tribute to Professor Oleh Hornykiewicz Wiener Klinische Wochenschrift, 118: 563-565

• Pifl C, Nagy G, Berényi S, Kattinger A, Reither H, Antus S (2005) Pharmacological characterization of ecstasy synthesis byproducts with recombinant human monoamine transporters J Pharmacol Exp Ther, 314: 346-354
• Xu J, Zhong N, Wang H, Elias JE, Kim CY, Woldman I, Pifl C, Gygi SP, Geula C, Yankner BA (2005) The Parkinson's Disease Associated DJ-1 Protein is a Transcriptional Co-Activator that Protects Against Neuronal Apoptosis Hum Mol Genet, 14: 1231-1241
• Woldman I, Reither H, Kattinger A, Hornykiewicz O, Pifl C (2005) Dopamine inhibits cell growth and cell cycle by blocking ribonucleotide reductase Neuropharmacology, 48: 525-537

• Rajput AH, Fenton ME , Di Paolo T, Sitte H, Pifl C Hornykiewicz O (2004) Human brain dopamine metabolism in levodopa-induced dyskinesia and wearing-off Parkinsonism & Related Disorders, 10: 221-226
• Pifl C, Khorchide M, Kattinger A, Reither H, Hardy J, Hornykiewicz O (2004) alpha-Synuclein selectively increases manganese-induced viability loss in SK-N-MC neuroblastoma cells expressing the human dopamine transporter Neurosci Lett, 354: 34-37
• Pifl C, Rebernik P, Kattinger A, Reither H (2004) Zn2+ modulates currents generated by the dopamine transporter: parallel effects on amphetamine-induced charge transfer and release Neuropharmacology, 46: 223-231
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• Pifl C, Kattinger A, Reither H, Hornykiewicz O (2002) Cellular effects of dopamine - beyond oxidative mechanisms Parkinsonism & Related Disorders, 8: 433-437
• Kristufek D, Rudorfer W, Pifl C, Huck S (2002) Organic cation transporter mRNA and function in the rat superior cervical ganglion J Physiol, 543: 117-134

• Pifl C, Caron MG (2002) The dopamine transporter: molecular biology, pharmacology and genetics. In: , Handbook of Experimental Pharmacology Springer Berlin Heidelberg New York: 257-297

• Sitte HH, Hiptmair B, Zwach J, Pifl C, Singer EA, Scholze P (2001) Quantitative analysis of inward and outward transport rates in cells stably expressing the cloned human serotonin transporter: inconsistencies with the hypothesis of facilitated exchange diffusion Mol Pharmacol, 59: 1129-1137
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• Pifl C, Zezula J, Spittler A, Kattinger A, Reither H, Caron MG, Hornykiewicz O (2001) Antiproliferative action of dopamine and norepinephrine in neuroblastoma cells expressing the human dopamine transporter FASEB J, 15: 1607-1609

• Pifl C, Sitte HH, Reither H, Singer EA (2000) The mechanism of the releasing action of amphetamine. Uptake, superfusion and electrophysiological studies on transporter-transfected cells Pure Appl Chem, 72: 1045-1050
• Sitte HH, Scholze P, Schloss P, Pifl C, Singer EA (2000) Characterization of carrier-mediated efflux in human embryonic kidney 293 cells stably expressing the rat serotonin transporter: a superfusion study J Neurochem, 74: 1317-1324
• Scholze P, Zwach J, Kattinger A, Pifl V, Singer EA, Sitte HH (2000) Transporter-mediated release: a superfusion study on human embryonic kidney cells stably expressing the human serotonin transporter J Pharmacol Exp Ther, 293: 870-878p

• Pifl C, Agneter E, Drobny H, Sitte HH, Singer EA (1999) Amphetamine reverses or blocks the operation of the human noradrenaline transporter depending on its concentration: superfusion studies on transfected cells Neuropharmacology, 38: 157-165
• Pifl C, Singer EA (1999) Ion dependence of carrier-mediated release in dopamine or norepinephrine transporter-transfected cells questions the hypothesis of faciliated exchange diffusion Mol Pharmacol, 56: 1047-1054
• Furukawa Y, Nygaard TG, Gutlich M, Rajput AH, Pifl C, DiStefano L, Chang LJ, Price K, Shimadzu M, Hornykiewicz O, Haycock JW, Kish SJ (1999) Striatal biopterin and tyrosine hydroxylase protein reduction in dopa-responsive dystonia Neurology, 53: 1032-1041

• Sitte HH, Huck S, Reither H, Boehm S, Singer EA, Pifl C (1998) Carrier-mediated release, transport rates and charge transfer induced by amphetamine, tyramine and dopamine in mammalian cells transfected with the human dopamine transporter J Neurochem, 71: 1289-1297

• Pifl C, Agneter E, Drobny H, Reither H, Singer EA (1997) Induction by low Na+ or Cl- of cocaine sensitive carrier-mediated efflux of amines from cells transfected with the cloned human catecholamine transporters Br J Pharmacol, 121: 205-212