Henning Fenselau, Group Leader at MPI for Metabolism Research, Köln will hold a seminar about - "Targeting hypothalamic neuroplasticity to cut excessive hunger"
Abstract / Short summary: Neuroplasticity - the brain's fundamental ability to remodel its connections - underlies learning, memory, and adaptive behavior. However, this same capacity can also encode persistent maladaptive states, including addiction, chronic pain, and obesity. Achieving selective reversal of such maladaptive neuroplasticity, without disrupting essential cognitive functions, remains a major therapeutic challenge. In this talk, I will present our work on excitatory plasticity in AgRP "hunger" neurons of the hypothalamus in feeding behavior and long-term body weight control.
I will then present our recent development of a stomach hormone-derived conjugate that
selectively suppresses this neuroplasticity within AgRP neurons while sparing other circuits,
establishing a targeted strategy to reduce hunger and treat obesity.
Hosted by: Tibor Harkany, Div. of Molecular Neurosciences, Center for Brain Research
Location:
Center for Brain Research, Spitalgasse 4, Large Seminar Room 1st Floor on the left.
Henning Fenselau, PhD
Group leader: Synaptic Transmission in Energy Homeostasis Max Planck Institute for Metabolism Research Gleueler Str. 50, 50931 Köln, Germany
