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Publications by Keimpema, Erik

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2024 Original Articles

  • Harkany T, Tretiakov E, Varela L, Jarc J, Rebernik P, Newbold S, Keimpema E, Verkhratsky A, Horvath T, Romanov R (2024) Molecularly stratified hypothalamic astrocytes are cellular foci for obesity Res Sq,

2023 Original Articles

  • Wirth U, Raabe K, Kalaba P, Keimpema E, Muttenthaler M, König B (2023) Photoswitchable Probes of Oxytocin and Vasopressin J Med Chem, 66 (21): 14853-14865
  • Zupančič M, Tretiakov E, Máté Z, Erdélyi F, Szabó G, Clotman F, Hökfelt T, Harkany T, Keimpema E (2023) Brain‐wide mapping of efferent projections of glutamatergic (Onecut3+) neurons in the lateral mouse hypothalamus Acta Physiol (Oxf)., 238 (3)
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  • Cinquina V, Keimpema E, Pollak D, Harkany T (2023) Adverse effects of gestational ω‐3 and ω‐6 polyunsaturated fatty acid imbalance on the programming of fetal brain development Neuroendocrinology,
    | https://pubmed.ncbi.nlm.nih.gov/37497857/ |

2022 Original Articles

  • Steffens S, Bakker J, Glat M, Keimpema E, Pollak D, Hökfelt T, Harkany T (2022) 3D‐printed design of a stereotaxic adaptor for the precision targeting of brain structures in infant mice Eur J Neurosci, 55 (3): 725-732
  • Krassnitzer M, Boisvert B, Beiersdorf J, Harkany T, Keimpema E (2022) Resident Astrocytes can Limit Injury to Developing Hippocampal Neurons upon THC Exposure Neurochem Res, 48 (4): 1242-1253

2021 Original Articles

  • Tortoriello G, Beiersdorf J, Romani S, Williams G, Cameron G, Mackie K, Williams M, Di Marzo V, Keimpema E, Doherty P, Harkany T (2021) Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB1 Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in Drosophila melanogaster Cannabis Cannabinoid Res, 6 (2): 119-136

2021 Reviews

  • Keimpema E, Di Marzo V, Harkany T (2021) Biological basis of cannabinoid medicines Science, 374 (6574): 1449-1450

2020 Original Articles

  • Beiersdorf J, Hevesi Z, Calvigioni D, Pyszkowski J, Romanov RA, Szodorai E, Lubec G, Shirran S, Botting CH, Kasper S, Guy GW, Gray R, Di Marzo V, Harkany T, Keimpema E (2020) Adverse effects of tetrahydrocannabinol on neuronal bioenergetics during postnatal brain development. JCI Insight, 5: e135418
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  • Cinquina V, Calvigioni D, Farlik M, Halbritter F, Gernedl V, Shirran SL, Fuszard MA, Botting CH, Poullet P, Piscitelli F, Máté Z, Szabó G, Yanagawa Y, Kasper S, Di Marzo V, Mackie K, McBain CJ, Bock C, Keimpema E, Harkany T (2020) Life-long epigenetic programming of cortical architecture by maternal ‘Western’ diet during pregnancy Mol Psychiatry, 25 (1): 22-36
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  • Romanov R, Tretiakov E, Kastriti M, Zupancic M, Häring M, Korchynska S, Popadin K, Benevento M, Rebernik P, Lallemend F, Nishimori K, Clotman F, Andrews W, Parnavelas J, Farlik M, Bock C, Adameyko I, Hökfelt T, Keimpema E, Harkany T (2020) Molecular design of hypothalamus development Nature, 582(7811): 246-252

2020 Reviews

  • Keimpema E, Harkany T, Alpár A (2020) The p(l)ot thickens: cannabinoid receptors on astroglial mitochondria coordinate animal behaviors by regulating lactate availability for neurons Signal Transduct Target Ther, 5 (1)

2019 Original Articles

  • Daba Feyissa D, Sialana F, Keimpema E, Kalaba P, Paunkov A, Engidawork E, Höger H, Lubec G, Korz V (2019) Dopamine type 1- and 2-like signaling in the modulation of spatial reference learning and memory Behav Brain Res, 362: 173-180
  • Korchynska S, Lutz M, Borók E, Pammer J, Cinquina V, Fedirko N, Irving A, Mackie K, Harkany T, Keimpema E (2019) GPR55 controls functional differentiation of self-renewing epithelial progenitors for salivation JCI Insight, 4 (4)
  • Korchynska S, Krassnitzer M, Malenczyk K, Prasad R, Tretiakov E, Rehman S, Cinquina V, Gernedl V, Farlik M, Petersen J, Hannes S, Schachenhofer J, Reisinger S, Zambon A, Asplund O, Artner I, Keimpema E, Lubec G, Mulder J, Bock C, Pollak D, Romanov R, Pifl C, Groop L, Hökfelt T, Harkany T (2019) Life‐long impairment of glucose homeostasis upon prenatal exposure to psychostimulants EMBO J., 39 (1)

2018 Original Articles

  • Alpár A, Zahola P, Hanics J, Hevesi Z, Korchynska S, Benevento M, Pifl C, Zachar G, Perugini J, Severi I, Leitgeb P, Bakker J, Miklosi AG, Tretiakov E, Keimpema E, Arque G, Tasan RO, Sperk G, Malenczyk K, Máté Z, Erdélyi F, Szabó G, Lubec G, Palkovits M, Giordano A, Hökfelt TG, Romanov RA, Horvath TL, Harkany T. (2018) Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress EMBO J., 37: e100087

2017 Original Articles

  • Milenkovic I, Stojanovic T, Aronica E, Fülöp L, Bozsó Z, Máté Z, Yanagawa Y, Adle-Biassette H, Lubec G, Szabó G, Harkany T, Kovács G, Keimpema E (2017) GABAA receptor subunit deregulation in the hippocampus of human foetuses with Down syndrome Brain Struct Funct,
  • Romanov R, Zeisel A, Bakker J, Girach F, Hellysaz A, Tomer R, Alpár A, Mulder J, Clotman F, Keimpema E, Hsueh B, Crow A, Martens H, Schwindling C, Calvigioni D, Bains J, Máté Z, Szabó G, Yanagawa Y, Zhang M, Rendeiro A, Farlik M, Uhlén M, Wulff P, Bock C, Broberger C, Deisseroth K, Hökfelt T, Linnarsson S, Horvath T, Harkany T (2017) Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes Nature Neurosci, 20 (2): 176-188
  • Hanics J, Szodorai E, Tortoriello G, Malenczyk K, Keimpema E, Lubec G, Hevesi Z, Lutz M, Kozsurek M, Puskár Z, Tóth Z, Wagner L, Kovács G, Hökfelt T, Harkany T, Alpár A (2017) Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration PNAS, 114 (10): E2006-E2015

2016 Original Articles

  • Calvigioni D, Máté Z, Fuzik J, Girach F, Zhang M, Varro A, Beiersdorf J, Schwindling C, Yanagawa Y, Dockray G, McBain C, Hökfelt T, Szabó G, Keimpema E, Harkany T (2016) Functional Differentiation of Cholecystokinin-Containing Interneurons Destined for the Cerebral Cortex Cereb. Cortex, : bhw094

2015 Original Articles

  • Penz O, Fuzik J, Kurek A, Romanov R, Larson J, Park T, Harkany T, Keimpema E (2015) Protracted brain development in a rodent model of extreme longevity Sci Rep, 5: 11592
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  • Malenczyk K, Keimpema E, Piscitelli F, Calvigioni D, Björklund P, Mackie K, Di Marzo V, Hökfelt T, Dobrzyn A, Harkany T (2015) Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture PNAS, 112 (45): E6185-E6194

2014 Original Articles

  • Keimpema E, Zheng K, Barde SS, Berghuis P, Dobszay MB, Schnell R, Mulder J, Luiten PG, Xu ZD, Runesson J, Langel Ü, Lu B, Hökfelt T, Harkany T (2014) GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain Cereb. Cortex,
  • Alpár A, Tortoriello G, Calvigioni D, Niphakis M, Milenkovic I, Bakker J, Cameron G, Hanics J, Morris C, Fuzik J, Kovacs G, Cravatt B, Parnavelas J, Andrews W, Hurd Y, Keimpema E, Harkany T (2014) Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling Nat Commun, 5
  • Tortoriello G, Morris CV, Alpar A, Fuzik J, Shirran SL, Calvigioni D, Keimpema E, Botting CH, Reinecke K, Herdegen T, Courtney M, Hurd YL, Harkany T (2014) Miswiring the brain: delta9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway Embo Journ, 33: 668-85

2014 Reviews

  • Keimpema E, Hökfelt T, Harkany T, Doherty P (2014) The molecular interplay between endocannabinoid and neurotrophin signals in the nervous system and beyond Eur J Neurosci, 39: 334-343
  • Calvigioni D, Hurd YL, Harkany T, Keimpema E, (2014) Neuronal substrates and functional consequences of prenatal cannabis exposure Child Adolesc Psychiatry Ment Health, Epub May 3, 2014

2013 Original Articles

  • Keimpema E, Alpár A, Howell F, Malenczyk K, Hobbs C, Hurd Y, Watanabe M, Sakimura K, Kano M, Doherty P, Harkany T (2013) Diacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signaling Sci Rep, 3 (1)
  • Keimpema E, Tortoriello G, Alpar A, Capsoni S, Arisi I, Calvigioni D, Hu S, Cattaneo A, Doherty P, Mackie K, Harkany T (2013) Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons PNAS, 110: 1935-1940
  • Malenczyk K, Jazurek M, Keimpema E, Silvestri C, Janikiewicz J, Mackie K, Di Marzo V, Redowicz MJ, Harkany T, Dobrzyn A (2013) CB1 Cannabinoid Receptors Couple to Focal Adhesion Kinase to Control Insulin Release J Biol Chem, 288: 32685-32699

2013 Reviews

  • Keimpema E, Calvigioni D, Harkany T (2013) Endocannabinoid signals in the developmental programming of delayed-onset neuropsychiatric and metabolic illnesses Biochem. Soc. Trans., 41: 1569-1576

2012 Reviews

  • Keimpema E, Straiker A, Mackie K, Harkany T, Hjerling‐Leffler J (2012) Sticking out of the crowd: the molecular identity and development of cholecystokinin‐containing basket cells Am J Physiol, 590 (4): 703-714

2011 Original Articles

  • Mulder J, Zilberter M, Pasquaré S, Alpár A, Schulte G, Ferreira S, Köfalvi A, Martín-Moreno A, Keimpema E, Tanila H, Watanabe M, Mackie K, Hortobágyi T, de Ceballos M, Harkany T (2011) Molecular reorganization of endocannabinoid signalling in Alzheimer’s disease Brain, 134 (4): 1041-1060

2011 Reviews

  • Keimpema E, Mackie K, Harkany T (2011) Molecular model of cannabis sensitivity in developing neuronal circuits Trends Pharmacol Sci, 32 (9): 551-561

2010 Original Articles

  • Keimpema E, Barabas K, Morozov Y, Tortoriello G, Torii M, Cameron G, Yanagawa Y, Watanabe M, Mackie K, Harkany T (2010) Differential Subcellular Recruitment of Monoacylglycerol Lipase Generates Spatial Specificity of 2-Arachidonoyl Glycerol Signaling during Axonal Pathfinding J Neurosci, 30 (42): 13992-14007

2009 Original Articles

  • Keimpema E, Fokkens M, Nagy Z, Agoston V, Luiten P, Nyakas C, Boddeke H, Copray J (2009) Early transient presence of implanted bone marrow stem cells reduces lesion size after cerebral ischaemia in adult rats Neuropathol Appl Neurobiol, 35 (1): 89-102

2008 Original Articles

  • Mulder J, Aguado T, Keimpema E, Barabás K, Ballester Rosado C, Nguyen L, Monory K, Marsicano G, Di Marzo V, Hurd Y, Guillemot F, Mackie K, Lutz B, Guzmán M, Lu H, Galve-Roperh I, Harkany T (2008) Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning Proc Natl Acad Sci USA, 105 (25): 8760-8765

2008 Reviews

  • Harkany T, Keimpema E, Barabás K, Mulder J (2008) Endocannabinoid functions controlling neuronal specification during brain development Mol Cell Endocrinol, 286 (1-2): S84-S90

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