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2024 Original Articles
- Garcia Moreno S, Limani F, Ludwig I, Gilbert C, Pifl C, Hnasko T, Steinkellner T (2024) Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration Exp. Neurol., 382: 114959
- Zifko U, Guendling K, Seet R, Kasper S (2024) Management of cognitive impairment associated with post-COVID-19 syndrome: recommendations for primary care Front. Pharmacol., 15: 1338235
| Weblink | - Bartova L, Fugger G, Dold M, Kautzky A, Bairhuber I, Kloimstein P, Fanelli G, Zanardi R, Weidenauer A, Rujescu D, Souery D, Mendlewicz J, Zohar J, Montgomery S, Fabbri C, Serretti A, Kasper S (2024) The clinical perspective on late-onset depression in European real-world treatment settings Int. J. Neuropsychopharmacol., 84: 59-68
| Weblink | - Kasper S, Volz H, Möller H, Schläfke S, Klement S, Anghelescu I, Seifritz E (2024) Lavender oil preparation Silexan is effective in mild-to-moderate major depression: a randomized, placebo- and reference-controlled trial Eur Arch Psychiatry Clin Neurosci,
| Weblink | - Szodorai E, Hevesi Z, Wagner L, Hökfelt T, Harkany T, Schnell R (2024) A hydrophobic groove in secretagogin allows for alternate interactions with SNAP-25 and syntaxin-4 in endocrine tissues Proc Natl Acad Sci USA, 121: e2309211121
- Harkany T, Tretiakov E, Varela L, Jarc J, Rebernik P, Newbold S, Keimpema E, Verkhratsky A, Horvath T, Romanov R (2024) Molecularly stratified hypothalamic astrocytes are cellular foci for obesity Res Sq,
- Harkany T, Tretiakov E, Varela L, Jarc J, Rebernik P, Newbold S, Keimpema E, Verkhratsky A, Horvath T, Romanov R (2024) Molecularly stratified hypothalamic astrocytes are cellular foci for obesity Nature, preprint
- Benevento M, Alpár A, Gundacker A, Afjehi L, Balueva K, Hevesi Z, Hanics J, Rehman S, Pollak D, Lubec G, Wulff P, Prevot V, Horvath T, Harkany T (2024) A brainstem–hypothalamus neuronal circuit reduces feeding upon heat exposure Nature, online
- Hevesi Z, Bakker J, Tretiakov E, Adori C, Raabgrund A, Barde S, Caramia M, Krausgruber T, Ladstätter S, Bock C, Hökfelt T, Harkany T (2024) Transient expression of the neuropeptide galanin modulates peripheral‑to‑central connectivity in the somatosensory thalamus during whisker development in mice Nat Commun, 15 : 2762
- Oliva V, Martone A, Fanelli G, Domschke K, Minelli A, Gennarelli M, Martini P, Bortolomasi M, Maron E, Squassina A, Pisanu C, Kasper S, Zohar J, Souery D, Montgomery S, Albani D, Forloni G, Ferentinos P, Rujescu D, Mendlewicz J, De Ronchi D, Baune B, Serretti A, Fabbri C, Potier M, van Westrhenen R, Rybakowski F, Mehta D, Dierssen M, Janzing J, Liò P (2024) Polygenic scores of subcortical brain volumes as possible modulators of treatment response in depression Neuroscience Applied, 3: 103937
| Weblink | - Kadriu B, Deng Z, Kraus C, Johnston J, Fijtman A, Henter I, Kasper S, Zarate C (2024) The impact of body mass index on the clinical features of bipolar disorder: A STEP-BD study Bipolar Disorders, 26: 160-175
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2024 Reviews
- Lochmann van Bennekom M, IntHout J, Gijsman H, Akdede B, Yağcıoğlu A, Barnes T, Galling B, Gueorguieva R, Kasper S, Kreinin A, Nielsen J, Nielsen R, Remington G, Repo-Tiihonen E, Schmidt-Kraepelin C, Shafti S, Xiao L, Correll C, Verkes R (2024) Efficacy and tolerability of antipsychotic polypharmacy for schizophrenia spectrum disorders. A systematic review and meta-analysis of individual patient data Schizophr Res, 272: 1-11
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2023 Original Articles
- Wirth U, Raabe K, Kalaba P, Keimpema E, Muttenthaler M, König B (2023) Photoswitchable Probes of Oxytocin and Vasopressin J Med Chem, 66 (21): 14853-14865
- Caramia M, Romanov R, Sideromenos S, Hevesi Z, Zhao M, Krasniakova M, Xu Z, Harkany T, Hökfelt T (2023) Neuronal diversity of neuropeptide signaling, including galanin, in the mouse locus coeruleus Proc Natl Acad Sci USA, 120 (31)
- Romanov R, Harkany T (2023) Grabbing neuropeptide signals in the brain Science, 382 (6672): 764-765
| Weblink | - Spies M, Silberbauer L, Kasper S (2023) Letter to the editor refers to “Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression” Decision making in treatment resistant depression: appeal for an individualized approach. N Engl J Med, 389 (10): 960
| Weblink | - Kasper S, Eckert A, Möller H, Volz H, Seifritz E (2023) Psychiatric manifestations of post-COVID-19 syndrome: the potential benefit of Silexan Int J Psychiatry Clin Pract, 27 (3): 285-291
| Weblink | - Wegener T, Edwards D, Kasper S (2023) The potential role of Rhodiola rosea L. extract WS® 1375 for patients with post-COVID-19 fatigue hb TIMES Schw Aerztej, 8 (1): 56-61
| Weblink | - Buchmayer F, Kasper S (2023) Overcoming the myths of esketamine administration: different and not difficult Front Psychiatry, 14
| Weblink | - Kasper S (2023) Cheers and a thank-you note from the founding chief-editor Int J Psychiatry Clin Pract, 27 (4): 319-322
| Weblink | - McIntyre R, Alsuwaidan M, Baune B, Berk M, Demyttenaere K, Goldberg J, Gorwood P, Ho R, Kasper S, Kennedy S, Ly‐Uson J, Mansur R, McAllister‐Williams R, Murrough J, Nemeroff C, Nierenberg A, Rosenblat J, Sanacora G, Schatzberg A, Shelton R, Stahl S, Trivedi M, Vieta E, Vinberg M, Williams N, Young A, Maj M (2023) Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions World Psychiatry, 22 (3): 394-412
| Weblink | - Kautzky A, Bartova L, Fugger G, Dold M, Souery D, Montgomery S, Zohar J, Mendlewicz J, Fabbri C, Serretti A, Rujescu D, Kasper S (2023) Age as a moderating factor of treatment resistance in depression Eur Psychiatry, 66: ahead of print
| Weblink | - Dold M, Bartova L, Volz H, Seifritz E, Möller H, Schläfke S, Kasper S (2023) Efficacy of Silexan in patients with anxiety disorders: a meta-analysis of randomized, placebo-controlled trials Eur Arch Psychiatry Clin Neurosci, 273 (7): 1615-1628
| Weblink | - Stöhrmann P, Godbersen G, Reed M, Unterholzner J, Klöbl M, Baldinger-Melich P, Vanicek T, Hahn A, Lanzenberger R, Kasper S, Kranz G (2023) Effects of bilateral sequential theta-burst stimulation on functional connectivity in treatment-resistant depression: first results J Affect Disord, 324: 660-669
| Weblink | - Murgaš M, Unterholzner J, Stöhrmann P, Philippe C, Godbersen G, Nics L, Reed M, Vraka C, Vanicek T, Wadsak W, Kranz G, Hahn A, Mitterhauser M, Hacker M, Kasper S, Lanzenberger R, Baldinger-Melich P (2023) Effects of bilateral sequential theta-burst stimulation on 5-HT1A receptors in the dorsolateral prefrontal cortex in treatment-resistant depression: a proof-of-concept trial Transl Psychiat, 13 (1)
| Weblink | - Kraus C, Kautzky A, Watzal V, Gramser A, Kadriu B, Deng Z, Bartova L, Zarate C, Lanzenberger R, Souery D, Montgomery S, Mendlewicz J, Zohar J, Fanelli G, Serretti A, Kasper S (2023) Body mass index and clinical outcomes in individuals with major depressive disorder: Findings from the GSRD European Multicenter Database J Affect Disord, 335: 349-357
| Weblink | - Bartova L, Fugger G, Dold M, Kautzky A, Fanelli G, Zanardi R, Albani D, Weidenauer A, Rujescu D, Souery D, Mendlewicz J, Montgomery S, Zohar J, Fabbri C, Serretti A, Kasper S (2023) Real-world characteristics of European patients receiving SNRIs as first-line treatment for major depressive disorder J Affect Disord, 332: 105-114
| Weblink | - Zupančič M, Tretiakov E, Máté Z, Erdélyi F, Szabó G, Clotman F, Hökfelt T, Harkany T, Keimpema E (2023) Brain‐wide mapping of efferent projections of glutamatergic (Onecut3+) neurons in the lateral mouse hypothalamus Acta Physiol (Oxf)., 238 (3)
| Weblink | - Cinquina V, Keimpema E, Pollak D, Harkany T (2023) Adverse effects of gestational ω‐3 and ω‐6 polyunsaturated fatty acid imbalance on the programming of fetal brain development Neuroendocrinology,
| https://pubmed.ncbi.nlm.nih.gov/37497857/ | - Pifl C, Reither H, Attems J, Zecca L (2023) Dopamine and vesicular monoamine transport loss supports incidental Lewy body disease as preclinical idiopathic Parkinson npj Parkinson's Disease, Jun 15;9(1):89
- Bhat S, El-Kasaby A, Kasture A, Boytsov D, Reichelt J, Hummel T, Sucic S, Pifl C, Freissmuth M, Sandtner W (2023) A mechanism of uncompetitive inhibition of the serotonin transporter eLife, 12/e82641
- Petersen J, Englmaier L, Artemov A, Poverennaya I, Mahmoud R, Bouderlique T, Tesarova M, Deviatiiarov R, Szilvásy-Szabó A, Akkuratov E, Pajuelo Reguera D, Zeberg H, Kaucka M, Kastriti M, Krivanek J, Radaszkiewicz T, Gömöryová K, Knauth S, Potesil D, Zdrahal Z, Ganji R, Grabowski A, Buhl M, Zikmund T, Kavkova M, Axelson H, Lindgren D, Kramann R, Kuppe C, Erdélyi F, Máté Z, Szabó G, Koehne T, Harkany T, Fried K, Kaiser J, Boor P, Fekete C, Rozman J, Kasparek P, Prochazka J, Sedlacek R, Bryja V, Gusev O, Adameyko I (2023) A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology Nat Commun, 14 (1): 3092
- Kasper S (2023) Fluch oder Segen von Benzodiazepinen: neu bewertet Jatros Neurologie & Psychiatrie , : 5
- Kasper S (2023) Evidenzbasis pflanzlicher Arzneimittel in der Psychopharmakotherapie Psychopharmakotherap, 30: 11-20
- Oliva V, Fanelli G, Kasper S, Zohar J, Souery D, Montgomery S, Albani D, Forloni G, Ferentinos P, Rujescu D, Mendlewicz J, De Ronchi D, Fabbri C, Serretti A (2023) Melancholic features and typical neurovegetative symptoms of major depressive disorder show specific polygenic patterns J Affect Disord, 320: 534-543
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2023 Reviews
- Harkany T, Hökfelt T (2023) Neuroglia: Function and Pathology by Alexei Verkhratsky and Arthur M. Butt Acta Physiol (Oxf)., 239 (2)
- Pallanti S, Zohar J, Kasper S, Möller H, Hollander E (2023) Revisiting benzodiazepines (GABA Enhancers):A transdiagnostic and precision medicine approach Psychiat Gen, 170: 65-72
| Weblink | - Bartova L, Lanzenberger R, Rujescu D, Kasper S (2023) Reply to: “The serotonin theory of depression: a systematic umbrella review of the evidence” published by Moncrieff J, Cooper RE, Stockmann T, Amendola S, Hengartner MP, Horowitz MA in Molecular Psychiatry (2022 Jul 20. doi: 10.1038/s41380-022-01661-0) Mol Psychiatry, 28 (8): 3153-3154
| Weblink | - Himmerich H, Lewis Y, Conti C, Mutwalli H, Karwautz A, Sjögren J, Uribe Isaza M, Tyszkiewicz-Nwafor M, Aigner M, McElroy S, Treasure J, Kasper S, Bailer U, Bulik C, Conti C, Zwaan M, Favaro A, Fernandez-Aranda F, Fetissov S, Hilbert A, Himmerich H, Wijbrand Hoek H, Kan C, Karpenko O, Karwautz A, Kasper S, Kaye W, Lewis Y, McElroy S, Mitchell J, Monteleone P, Mörkl S, Müller D, Mutwalli H, Nazar B, Papežová H, Sjögren J, Steiger H, Stein D, Szabo C, Tyszkiewicz-Nwafor M, Voderholzer U, Uribe Isaza M, Wade T, Wranik W, Yoshiuchi K, (2023) World Federation of Societies of Biological Psychiatry (WFSBP) guidelines update 2023 on the pharmacological treatment of eating disorders World J Biol Psychiatry, 24: 643-706
| Weblink | - Bartova L, Dold M, Fugger G, Weidenauer A, Rujescu D, Kasper S (2023) Silexan for treatment of anxiety and depression in the context of COVID-19 Eur Neuropsychopharmacol, 70: 47-48
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2023 Book Chapters
- Inada K, Yamawaki S, Kanba S, Shinozaki G, Kasper S (2023) General Principles of Pharmacologic Therapy. In: Springer Verlag, Springer Verlag Heidelberg, New York Springer Verlag, Heidelberg, New York: ahead of print
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2022 Original Articles
- Steffens S, Bakker J, Glat M, Keimpema E, Pollak D, Hökfelt T, Harkany T (2022) 3D‐printed design of a stereotaxic adaptor for the precision targeting of brain structures in infant mice Eur J Neurosci, 55 (3): 725-732
- Krassnitzer M, Boisvert B, Beiersdorf J, Harkany T, Keimpema E (2022) Resident Astrocytes can Limit Injury to Developing Hippocampal Neurons upon THC Exposure Neurochem Res, 48 (4): 1242-1253
- Korchynska S, Rebernik P, Pende M, Boi L, Alpár A, Tasan R, Becker K, Balueva K, Saghafi S, Wulff P, Horvath T, Fisone G, Dodt H, Hökfelt T, Harkany T, Romanov R (2022) A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice Nat Commun, 13 (1)
- Seifritz E, Kasper S, Möller H, Volz H, Müller W, Eckert A, Hatzinger M (2022) Effect of anxiolytic drug silexan on sleep – a narrative review World J Biol Psychiatry, 23 (7): 493-500
| Weblink | - Pain O,..,the GSRD Consortium, the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, McIntosh AM, Lewis CM (2022) Identifying the Common Genetic Basis of Antidepressant Response Biological Psychiatry GOS, 2 (2): 115-126
| Weblink | - Panariello F, Kasper S, Zohar J, Souery D, Montgomery S, Ferentinos P, Rujescu D, Mendlewicz J, De Ronchi D, Serretti A, Fabbri C (2022) Characterisation of medication side effects in patients with mostly resistant depression in a real-world setting World J Biol Psychiatry, 24 (5): 439-448
| Weblink | - Roca M, Bonelli A, Cattaneo A, Comandini A, Di Dato G, Heiman F, Pegoraro V, Kasper S, Volz H, Palao D (2022) Factors associated with sick leave duration in patients suffering from major depressive disorder initiating antidepressant treatment: a real-world evidence study in Germany and Spain Int J Psychiatry Clin Pract, 27 (1): 59-68
| Weblink | - Silberbauer L, Rischka L, Vraka C, Hartmann A, Godbersen G, Philippe C, Pacher D, Nics L, Klöbl M, Unterholzner J, Stimpfl T, Wadsak W, Hahn A, Hacker M, Rujescu D, Kasper S, Lanzenberger R, Gryglewski G (2022) ABCB1 variants and sex affect serotonin transporter occupancy in the brain Mol Psychiatry, 27 (11): 4502-4509
| Weblink | - Bandelow B, Allgulander C, Baldwin D, Costa D, Denys D, Dilbaz N, Domschke K, Eriksson E, Fineberg N, Hättenschwiler J, Hollander E, Kaiya H, Karavaeva T, Kasper S, Katzman M, Kim Y, Inoue T, Lim L, Masdrakis V, Menchón J, Miguel E, Möller H, Nardi A, Pallanti S, Perna G, Rujescu D, Starcevic V, Stein D, Tsai S, Van Ameringen M, Vasileva A, Wang Z, Zohar J (2022) World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders – Version 3. Part I: Anxiety disorders World J Biol Psychiatry, 24 (2): 79-117
| Weblink | - Bandelow B, Allgulander C, Baldwin D, Costa D, Denys D, Dilbaz N, Domschke K, Hollander E, Kasper S, Möller H, Eriksson E, Fineberg N, Hättenschwiler J, Kaiya H, Karavaeva T, Katzman M, Kim Y, Inoue T, Lim L, Masdrakis V, Menchón J, Miguel E, Nardi A, Pallanti S, Perna G, Rujescu D, Starcevic V, Stein D, Tsai S, Van Ameringen M, Vasileva A, Wang Z, Zohar J (2022) World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders – Version 3. Part II: OCD and PTSD World J Biol Psychiatry, 24 (2): 118-134
| Weblink | - Ludwig B, Carlberg L, Kienesberger K, Swoboda P, Swoboda M, Bernegger A, Koller R, Inaner M, Fuxjäger M, Zotter M, Schmelzle N, Senft B, Meisner L, Fischer-Hansal D, Huber J, Schoenthaler S, Kapusta N, Haslacher H, Aigner M, Weinhaeusel A, Kasper S, Schosser A (2022) Oxytocin receptor gene methylation as a molecular marker for severity of depressive symptoms in affective disorder patients BMC Psychiatry, 22 (1): 1-8
| Weblink | - L. Bartova, G. Fugger, M. Dold, S. Kasper (2022) Therapieoptionen bei Angsterkrankungen unter Berücksichtigung der Phyto- Psychopharmakotherapie Journal für Neurologie, Neurochirurgie und Psychiatrie, 23: 124-130
- Vanicek T, Reed M, Seiger R, Godbersen G, Klöbl M, Unterholzner J, Spurny-Dworak B, Gryglewski G, Handschuh P, Schmidt C, Kraus C, Stimpfl T, Rupprecht R, Kasper S, Lanzenberger R (2022) Increased left dorsolateral prefrontal cortex density following escitalopram intake during relearning: a randomized, placebo-controlled trial in healthy humans Ther Adv Psychopharmacol, 12: 1-15
| Weblink | - Zhang B, Stöhrmann P, Godbersen G, Unterholzner J, Kasper S, Kranz G, Lanzenberger R (2022) Normal component of TMS-induced electric field is correlated with depressive symptom relief in treatment-resistant depression Brain Stimul, 15 (5): 1318-1320
| Weblink | - Bartova L, Fugger G, Dold M, Kautzky A, Rujescu D, Kasper S (2022) Psychotherapy’s Role for Treatment-Resistant Depression? Am J Psychiatry, 179 (9): 687-687
| Weblink | - Fallatah W, Cui W, Di Pietro E, Carter G, Pounder B, Dorninger F, Pifl C, Moser A, Berger J, Braverman N (2022) A Pex7 Deficient Mouse Series Correlates Biochemical and Neurobehavioral Markers to Genotype Severity—Implications for the Disease Spectrum of Rhizomelic Chondrodysplasia Punctata Type 1 Front Cell Dev Biol, 10
| Article (PDF) | - Spurny-Dworak B, Godbersen GM, Reed MB, Unterholzner J, Vanicek T, Baldinger-Melich P, Hahn A, Kranz GS, Bogner W, Lanzenberger R, Kasper S (2022) The impact of theta-burst stimulation on cortical GABA and glutamate in treatment-resistant depression: A surface-based MRSI analysis approach. Front Mol Neurosci, : 913274
| Weblink | - Bartova L, Dold M, Volz HP, Seifritz E, Möller HJ, Kasper S (2022) Beneficial effects of Silexan on co-occurring depressive symptoms in patients with subthreshold anxiety and anxiety disorders – randomized, placebo-controlled trials revisited. Eur Arch Psychiatry Clin Neurosci,
| Weblink | - Fanelli G, Domschke K, Minelli A, Gennarelli M, Martini P, Bortolomasi M, Maron E, Squassina A, Kasper S, Zohar J, Souery D, Montgomery S, Albani D, Forloni G, Ferentinos P, Rujescu D, Mendlewicz J, De Ronchi D, Baune BT, European College of Neuropsychopharmacology (ECNP) Pharmacogenomics & Transcriptomics Thematic Working Group, Serretti A, Fabbri C (2022) A meta-analysis of polygenic risk scores for mood disorders, neuroticism, and schizophrenia in antidepressant response. Eur Neuropsychopharmacol, 55: 86-95
| Weblink | - Oliva V, Fanelli G, Kasper S; Zohar J, Souery D; Montgomery S, Albani D; Forloni G, Ferentinos P, Rujescu D, Mendlewicz J, Kas M, De Ronchi D, Fabbri C, Serretti A (2022) Social withdrawal as a trans-diagnostic predictor of short-term remission. A meta-analysis of five clinical cohorts. Int Clin Psychopharmacol, 37: 38 – 45
| Weblink | - Fugger G, Bartova L, Dold M, Fabbri C, Fanelli G, Zanardi R, Kautzky A, Zohar J, Souery D, Mendlewicz J, Montgomery S, Rujescu D, Serretti A, Kasper S (2022) Evidence on Sociodemographic and Clinical Correlates of Antidepressant Combination or Augmentation with Second-Generation Antipsychotics in Major Depressive Disorder. Prog in Neuropsychopharmaco & Biolog. Psychiatry , 114: 110480
| Weblink | - Fugger G, Bartova L, Fabbri C, Fanelli G, Zanardi R, Dold M, Kautzky A, Rujescu D, Souery D, Mendlewicz J, Zohar J, Montgomery S, Serretti A, Kasper S (2022) The Sociodemographic and Clinical Phenotype of European Patients with Major Depressive Disorder Undergoing first-line Antidepressant Treatment with NaSSAs J Affect Disord, : 225-234
| Weblink | - Fugger G, Bartova L, Fabbri C, Fanelli G, Dold M, Swoboda MMM, Kautzky A, Zohar J, Souery D, Mendlewicz J, Montgomery S, Rujescu D, Serretti A, Kasper S (2022) The Sociodemographic and Clinical Profile of Patients with Major Depressive Disorder Receiving SSRIs as First-line Antidepressant Treatment in European Countries. Eur Arch Psychiatry Clin Neurosci,
| Weblink | - de Bardeci M, Greil W, Stassen H, Willms J, Köberle U, Bridler R, Hasler G, Kasper S, Rüther E, Bleich S, Toto S, Grohmann R, Seifert J (2022) Dear Doctor Letters regarding Citalopram and Escitalopram: Guidelines vs real world data. Eur Arch Psychiatry Clin Neurosci,
| Weblink | - Bartova L, Fugger G, Dold M, Kautzky A, Swoboda MMM, Rujescu D, Zohar J, Souery D, Mendlewicz J, Montgomery S, Fabbri C, Serretti A, Kasper S (2022) The Choice of either Quetiapine or Aripiprazole as Augmentation Treatment in a European Naturalistic Sample of Patients with Major Depressive Disorder. Int. J. Neuropsychopharmacol., 25: 118-127
| Weblink | - Calabrò M, Fabbri C, Kasper S, Zohar J, Souery D, Montgomery S, Albani D, Forloni G, Ferentinos P, Rujescu D, Mendlewicz J, De Ronchi D, Serretti A, Crisafulli C (2022) Metabolizing status of CYP2C19 in response and side effects to medications for depression: results from a naturalistic study. Eur Neuropsychopharmacol, 56: 100-111
| Weblink | - Kasper S (2022) Initiating Antidepressant Medication: What is the Most Important Factor? Adv in Therapy, : S5-S12,
| Weblink | - Sarris J, Ravindran A, Yatham LN, Marx W, Rucklidge J, McIntyre RS, Akhondzadeh S, Benedetti F, Caneo C, Cramer H, Cribb L, de Manincor M, Dean O, Deslandes AC, Freeman MP, Gangadhar B, Harvey BH, Kasper S, Lake J, Lopresti A, Lu L, Metri NJ, Mischoulon D, Ng C, Nishi D, Rahimi R, Seedat S, Sincliar J, Su KP, Zhang ZJ, Berk M (2022) Clinician Guidelines for the Treatment of Psychiatric Disorders with Nutraceuticals and Phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce. World J Biol Psychiatry, 23: 424-455
| Weblink | - Volz H, Bartečků E, Bartova L, Bessa J, De Berardis D, Dragasek J, Kozhuharov H, Ladea M, Lazáry J, Roca M, Usov G, Wichniak A, Godman B, Kasper S (2022) Sick leave duration as a potential marker of functionality and disease severity in depression Int J Psychiatry Clin Pract, 26 (4): 406-416
| Weblink | - Komorowski A, Murgas M, Vidal R, Singh A, Gryglewski G, Kasper S, Wiltfang J, Lanzenberger R, Goya-Maldonado R (2022) Regional gene expression patterns are associated with task-specific brain activation during reward and emotion processing measured with functional MRI Human Brain Mapping, 43: 5266-5280
| Weblink | - Fanelli G, Sokolowski M, Wasserman D, European College of Neuropsychopopharmacology (ECNP) Network on Suicide Research and Prevention, Kasper S, Zohar J, Souery D, Montgomery S, Albani D, Forloni G, Ferentinos P, Rujescu D, Mendlewicz J, De Ronchi D, Serretti A, Fabbri C (2022) Polygenic risk scores for neuropsychiatric, inflammatory, and cardio-metabolic traits highlight possible genetic overlap with suicide attempt and treatment-emergent suicidal ideation Am. J. Med. Genet. B Neuropsychiatr. Genet. , : 74-85
| Weblink | - Pain O, Hodgson K, Trubetskoy V, Ripke S, Marshe VS, Adams MJ, Byrne EM, Campos AI, Carillo-Roa T, Cattaneo A, Als TD, Souery D, Dernovsek MZ, Fabbri C, Hayward C, Jenigsberg N, Hauser J, Kennedy JL, Lenze EJ, Lewis G, Müller DJ, Martin NG, Mulsant BH, Mors O, Perroud N, Porteous DJ, Renteria ME, Reynolds III CF, Rietschel M, Uher R, Wigmore EM, Maier W, Wray NR, Aitchison KJ, Arolt V, Baune BT, Biernacka JM, Bondolfi G, Domschke K, Kato M, Li QS, Liu YL, Serretti A, Tsai SJ, Turecki G, Weinshilboum R, the GSRD Consortium, the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, McIntosh AM, Lewis CM (2022) Identifying the common genetic basis of antidepressant response. Biol Psychiatry, 2: 115-126
| Weblink | - Generoso M, Taiar I, Cordeiro Q, Shiozawa P, Kasper S (2022) Cariprazine for treating psychosis: an updated meta-analysis Int J Psychiatry Clin Pract, 27 (1): 107-109
| Weblink | - Friedrich ME, Grohmann R, Rabl U, Winkler D, Konstantinidis A, Engel R, Seifert J, Toto S, Stübner S, Frey R, Kasper S (2022) Incidence of drug-induced delirium during treatment with antidepressants or antipsychotics – a drug surveillance report of German-speaking countries between 1993 and 2016. Int. J. Neuropsychopharmacol., 25: 556-566
| Weblink | - Vanicek T, Unterholzner J, Lanzenberger R, Naderi-Heiden A, Kasper S, Praschak-Rieder N (2022) Intravenous esketamine leads to an increase in impulsive and suicidal behaviour in a patient with recurrent major depression and borderline personality disorder World J Biol Psychiatry, 23 (9): 715-718
| Weblink | - Zambon A, Rico L, Herman M, Gundacker A, Telalovic A, Hartenberger L, Kuehn R, Romanov R, Hussaini S, Harkany T, Pollak D (2022) Gestational immune activation disrupts hypothalamic neurocircuits of maternal care behavior Mol Psychiatry,
2022 Reviews
- Kasper S (2022) Rasch wirkende Antidepressiva bei Major Depression und therapieresistenter Depression Jatros Neurologie & Psychiatrie , 5: 38
- Kasper S, Sachs G, Erfurth A, Rujescu D, Bach M, Baldinger-Melich P, Bartova L, Conca A, Dold M, Frey R, Goessler R, Hausmann A, Lan-zenberger R, Lehofer M, Marksteiner J, Naderi-Heiden A, Plener P, Praschak-Rieder N, Rados C, Schosser A, Sperner-Unterweger B, Spies M, Winkler D (2022) Angststörungen Psychopharmakotherapie Jatros Neurologie & Psychiatrie ,
- Möller HJ, Kasper S (2022) Serotonin-Theorie der Depression in Umbrella-Review nicht bestätigt? Psychopharmakotherap, 29: 187-189
- Kasper S (2022) Suizidalität: Von einer psychiatrischen zu einer juristischen Sichtweise? Jatros Neurologie & Psychiatrie , : 24-25
- Kasper S. (2022) Suizidalität: Von einer psychiatrischen zu einer juristischen Sichtweise? Journal für Neurologie, Neurochirurgie und Psychiatrie, 23: 5-6
- Kasper S, Erfurth A, Sachs G, Aichhorn W, Bartova L, Bengesser S, Buchmayer F, Deisenhammer E, Di Pauli J, Dold M, Falkai P, Frey R, Glück K, Hofer A, Holsboer-Trachsler E, Kautzky A, Konstantinidis A, Kraus C, Lehofer M, Marksteiner J, Mitschek M, Mörkl S, Oberlerchner H, Plener P, Psota G, Rados C, Rainer M, Schosser A, Seifritz E, Silberbauer C, Winkler D, Wunsch C, Zwanzger P (2022) Treatment-resistant Depression: Diagnosis and Treatment, Konsensus-Statement Jatros Neurologie & Psychiatrie , : 1-31
- Fugger G, Bartova L, Dold M, Kasper S (2022) Die therapieresistente Depression (TRD) – Herausforderungen und praktisches Management. psychopraxis. neuropraxis, : 49 – 54
| Weblink | - Kasper S (2022) Is treatment-resistant depression really resistant? Eur Neuropsychopharmacol, : 44–46
| Weblink | - Volz HP, Stirnweiß J, Kasper S, Möller HJ, Seifritz E (2022) Subthreshold depression – concept, operationalization and epidemiological data. A scoping review. Int J Psychiatry Clin Pract, 27: 92-106
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2021 Original Articles
- Tortoriello G, Beiersdorf J, Romani S, Williams G, Cameron G, Mackie K, Williams M, Di Marzo V, Keimpema E, Doherty P, Harkany T (2021) Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB1 Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in Drosophila melanogaster Cannabis Cannabinoid Res, 6 (2): 119-136
- Mitschek M, Vanicek T, Unterholzner J, Kraus C, Weidenauer A, Naderi-Heiden A, Frey R, Silberbauer L, Gryglewski G, Papageorgiou K, Winkler D, Dold M, Kasper S, Praschak-Rieder N, Bartova L (2021) How to prevent and manage hyperammonemic encephalopathies in valproate therapy J Affect Disord, 5: 100186
| Weblink | - Möller H, Falkai P, Kasper S (2021) Obituary – Prof. Dr. Hanns Hippius Int. J. Neuropsychopharmacol., 24: 856-857
| Weblink | - Winkler D, Grohmann R, Friedrich ME, Toto S, Bleich S, Seifert J, Anastasios Konstantinidis A, Shariat SF, Kasper S, Pjrek E (2021) Urological adverse drug reactions of psychotropic medication in psychiatric inpatients – A drug surveillance report of German-speaking countries J Psychiatr Res, 144: 412–420
| Weblink | - Bartova L, Kasper S (2021) Chronobiologie der Depression Psychiatr Danub., 33: 446-453
| Weblink | - Sauerzopf U, Weidenauer A, Dajic I, Bauer M, Bartova L, Meyer B, Nics L, Philippe C, Pfaff S, Pichler V, Mitterhauser M, Wadsak W, Hacker M, Kasper S, Lanzenberger R, Pezawas L, Praschak-Rieder N, Willeit M (2021) Disrupted relationship between blood glucose and brain dopamine D2/3 receptor binding in patients with first-episode schizophrenia Neuroimage Clin, 32: 102813
| Weblink | - Gryglewski G, Lanzenberger R, Silberbauer LR, Pacher D, Kasper S, Rupprecht R, Frey R, Baldinger-Melich P (2021) Meta-analysis of brain structural changes after electroconvulsive therapy in depression Brain Stimul, 14: 927-937
| Weblink | - Kasper S, Bonelli A, Cattaneo A, Comandini A, Di Dato G, Heiman F, Pegoraro V, Palao D, Roca M, Volz HP (2021) Predictors of sick leave days in patients affected by major depressive disorder receiving antidepressant treatment in general practice setting in Germany Int J Psychiatry Clin Pract, 24: 393-402
- Kasper S, Young AH, Vieta E, Goodwin G, Meyer-Lindenberg A (2021) Letter to BJPsych in response to Horowitz and Moncrieff (electronic response to Horowitz MA and Moncrieff J) Are we repeating mistakes of the past? A review of the evidence for esketamine. Br J Psychiatry, 219: 619-620
| Weblink | - Seifritz E, Möller HJ, Volz HP, Müller WE, Hopyan T, Wacker A, Schläfke S, Kasper S (2021) No abuse potential of Silexan in healthy recreational drug users: a randomised controlled trial Int. J. Neuropsychopharmacol., 24: 171-180
- Dold M, Bartova L, Fugger G, Mitschek MMM, Fabbri C, Serretti A, Mendlewicz J, Souery D, Zohar J, Montgomery S, Kasper S (2021) Pregabalin augmentation of antidepressants in major depression – results from a European multicenter study J Affect Disord, 296: 485-492
| Weblink | - da Silva SR, Kalaba P, Fabisikova A, Zehl M, Dragacevic V, Ribeiro dos Anjos L, Neill PJ, Wieder M, Prado-Roller A, Gajic N, Palaretti V, da Silva GVJ, Pifl C, Lubec G, Gonzalez ERP (2021) Synthesis and dopamine receptor binding of dihydrexidine and SKF 38393 catecholamine-based analogues Amino Acids, Published Online: 29 November 2021
- Volz H, Saliger J, Kasper S, Möller H, Seifritz E (2021) Subsyndromal generalised anxiety disorder: operationalisation and epidemiology – a systematic literature survey Int J Psychiatry Clin Pract,
| Weblink | - Bartova L, Dold M, Fugger G, Kautzky A, Mitschek M, Weidenauer A, Hienert M, Frey R, Mandelli L, Zohar J, Mendlewicz J, Souery D, Montgomery S, Fabbri C, Serretti A, Kasper S (2021) Sex‐related effects in major depressive disorder: Results of the European Group for the Study of Resistant Depression Depress Anxiety,
| Weblink | - Rischka L, Godbersen G, Pichler V, Michenthaler P, Klug S, Klöbl M, Ritter V, Wadsak W, Hacker M, Kasper S, Lanzenberger R, Hahn A (2021) Reliability of task-specific neuronal activation assessed with functional PET, ASL and BOLD imaging Cereb Blood Flow Metab, : 0271678X2110205
| Weblink | - Ludwig B, Carlberg L, Kienesberger K, Swoboda P, Mitschek M, Bernegger A, Koller R, Inaner M, Senft B, Meisner L, Fischer-Hansal D, Affenzeller A, Huber J, Schoenthaler S, Kapusta N, Haslacher H, Aigner M, Weinhaeusel A, Kasper S, Schosser A (2021) Monoamino Oxidase a Gene Single-Nucleotide Polymorphisms and Methylation Status and the Risk of Violent Suicide Attempts in Affective Disorder Patients Front Psychiatry, 12
| Weblink | - Bartova L, Fugger G, Dold M, Swoboda M, Zohar J, Mendlewicz J, Souery D, Montgomery S, Fabbri C, Serretti A, Kasper S (2021) Combining psychopharmacotherapy and psychotherapy is not associated with better treatment outcome in major depressive disorder - evidence from the European Group for the Study of Resistant Depression J Psychiatr Res, 141: 167-175
| Weblink | - Lubec J, Kalaba P, Hussein A, Feyissa D, Kotob M, Mahmmoud R, Wieder O, Garon A, Sagheddu C, Ilic M, Dragačević V, Cybulska-Klosowicz A, Zehl M, Wackerlig J, Sartori S, Ebner K, Kouhnavardi S, Roller A, Gajic N, Pistis M, Singewald N, Leban J, Korz V, Malikovic J, Plasenzotti R, Sitte H, Monje F, Langer T, Urban E, Pifl C, Lubec G (2021) Reinstatement of synaptic plasticity in the aging brain through specific dopamine transporter inhibition Mol Psychiatry,
- Milenkovic I, Bartova L, Papageorgiou K, Kasper S, Traub-Weidinger T, Winkler D (2021) Case Report: Bupropion Reduces the [123I]FP-CIT Binding to Striatal Dopamine Transporter Front Psychiatry, 12: 631357
| Weblink | - Bhat S, Niello M, Schicker K, Pifl C, Sitte H, Freissmuth M, Sandtner W (2021) Handling of intracellular K+ determines voltage dependence of plasmalemmal monoamine transporter function eLife, 10
- Patthy �, Murai J, Hanics J, Pintér A, Zahola P, Hökfelt T, Harkany T, Alpár A (2021) Neuropathology of the Brainstem to Mechanistically Understand and to Treat Alzheimer’s Disease J Clin Med, 10 (8): 1555
- Höflich A, Kraus C, Pfeiffer R, Seiger R, Rujescu D, Zarate C, Kasper S, Winkler D, Lanzenberger R (2021) Translating the immediate effects of S-Ketamine using hippocampal subfield analysis in healthy subjects-results of a randomized controlled trial Transl Psychiat, 11 (1): 200
| Weblink | - Dold M, Bartova L, Fugger G, Kautzky A, Mitschek M, Fabbri C, Montgomery S, Zohar J, Souery D, Mendlewicz J, Serretti A, Kasper S (2021) Melancholic features in major depression – a European multicenter study Prog Neuropsychopharmacol Biol Psychiatry, 110: 110285
| Weblink | - McIntyre R, Rosenblat J, Nemeroff C, Sanacora G, Murrough J, Berk M, Brietzke E, Dodd S, Gorwood P, Ho R, Iosifescu D, Lopez Jaramillo C, Kasper S, Kratiuk K, Lee J, Lee Y, Lui L, Mansur R, Papakostas G, Subramaniapillai M, Thase M, Vieta E, Young A, Zarate C, Stahl S (2021) Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation Am J Psychiatry, 178 (5): 383-399
| Weblink | - von Känel R, Kasper S, Bondolfi G, Holsboer‐Trachsler E, Hättenschwiler J, Hatzinger M, Imboden C, Heitlinger E, Seifritz E (2021) Therapeutic effects of Silexan on somatic symptoms and physical health in patients with anxiety disorders: A meta‐analysis Brain and Behavior, 11 (4): e01997
| Weblink | - Bartova L, Dold M, Fugger G, Kautzky A, Mitschek M, Weidenauer A, Handschuh P, Frey R, Mandelli L, Zohar J, Mendlewicz J, Souery D, Montgomery S, Fabbri C, Serretti A, Kasper S (2021) The Role of Relationship Status in Major Depressive Disorder Results of the European Group for the Study of Resistant Depression J Affect Disord, 286: 149-157
| Weblink | - Seiger R, Gryglewski G, Klöbl M, Kautzky A, Godbersen G, Rischka L, Vanicek T, Hienert M, Unterholzner J, Silberbauer L, Michenthaler P, Handschuh P, Hahn A, Kasper S, Lanzenberger R (2021) The influence of acute SSRI administration on white matter microstructure in patients suffering from major depressive disorder and healthy controls Int J Neuropsychopharmacol, 24 (7): 542-550
| Weblink | - Sarris J, Marx W, Ashton M, Ng C, Galvao-Coelho N, Ayati Z, Zhang Z, Kasper S, Ravindran A, Harvey B, Lopresti A, Mischoulon D, Amsterdam J, Yatham L, Berk M (2021) Plant-based Medicines (Phytoceuticals) in the Treatment of Psychiatric Disorders: A Meta-review of Meta-analyses of Randomized Controlled Trials: Les médicaments à base de plantes (phytoceutiques) dans le traitement des troubles psychiatriques: une méta-revue des méta-analyses d’essais randomisés contrôlés Can J Psychiatry, 6: 849-862
| Weblink | - McAllister-Williams R, Arango C, Blier P, Demyttenaere K, Falkai P, Gorwood P, Hopwood M, Javed A, Kasper S, Malhi G, Soares J, Vieta E, Young A, Papadopoulos A, Rush A (2021) Reconceptualising treatment-resistant depression as difficult-to-treat depression Lancet Psychiatry, 8 (1): 14-15
| Weblink | - Fabbri C, Kasper S, Zohar J, Souery D, Montgomery S, Albani D, Forloni G, Ferentinos P, Rujescu D, Mendlewicz J, Serretti A, Lewis C (2021) Cost-effectiveness of genetic and clinical predictors for choosing combined psychotherapy and pharmacotherapy in major depression J Affect Disord, 279: 722-729
| Weblink | - Fabbri C, Kasper S, Zohar J, Souery D, Montgomery S, Albani D, Forloni G, Ferentinos P, Rujescu D, Mendlewicz J, De Ronchi D, Riva M, Lewis C, Serretti A (2021) Drug repositioning for treatment-resistant depression: Hypotheses from a pharmacogenomic study Prog Neuropsychopharmacol Biol Psychiatry, 104: 110050
| Weblink | - Fanelli G, Benedetti F, Kasper S, Zohar J, Souery D, Montgomery S, Albani D, Forloni G, Ferentinos P, Rujescu D, Mendlewicz J, Serretti A, Fabbri C (2021) Higher polygenic risk scores for schizophrenia may be suggestive of treatment non-response in major depressive disorder Prog Neuropsychopharmacol Biol Psychiatry, : 110170
| Weblink | - Ionescu DF, Fu DJ, Qiu X, Lane R, Lim P, Kasper S, Hough D, Drevets WC, Manji H, Canuso CM (2021) Esketamine Nasal Spray for Rapid Reduction of Depressive Symptoms in Patients With Major Depressive Disorder Who Have Active Suicide Ideation With Intent: Results of a Phase 3, Double-Blind, Randomized Study (ASPIRE II) Int J Neuropsychopharmacol, 24(1): 22-31
| Weblink | - Kautzky A, Möller H, Dold M, Bartova L, Seemüller F, Laux G, Riedel M, Gaebel W, Kasper S (2021) Combining machine learning algorithms for prediction of antidepressant treatment response Acta Psychiatr Scand, 143 (1): 36-49
| Weblink | - Möller H, Volz H, Seifritz E, Müller H, Kenntner-Mabiala R, Kaussner Y, Schoch S, Kasper S (2021) Silexan does not affect driving performance after single and multiple dose applications: Results from a double-blind, placebo and reference-controlled study in healthy volunteers J Psychiatr Res, 136: 543-551
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2021 Reviews
- Cinquina V, Weidenauer A, Kasper S, Harkany T (2021) Cannabinoids in the brain: their mechanism of action in relation to neuropsychiatric disorders Jatros Neurologie & Psychiatrie , 6: 35-38
- Keimpema E, Di Marzo V, Harkany T (2021) Biological basis of cannabinoid medicines Science, 374 (6574): 1449-1450
- Kasper S, Erfurth A, Sachs G, Aichhorn W, Bartova L, Bengesser S, Buchmayer F, Deisenhammer E, Di Pauli J, Dold M, Falkai P, Frey R, Glück K, Hofer A, Holsboer-Trachsler E, Kautzky A, Konstantinidis A, Kraus C, Lehofer M, Marksteiner J, Mitschek M, Mörkl S, Oberlerchner H, Plener P, Psota G, Rados C, Rainer M, Schosser A, Seifritz E, Silberbauer C, Winkler D, Wunsch C, Zwanzger P (2021) Therapieresistente Depression: Diagnose und Behandlung, Konsensus-Statement Jatros Neurologie & Psychiatrie , Sonderheft 03/2021: 1-32
- Kasper S (2021) Neue Behandlungsperspektiven bei der sog. behandlungsresistenten Depression (TRD) Journal für Neurologie, Neurochirurgie und Psychiatrie, 1: 3-5
| Weblink | - Calabrò M, Fabbri C, Kasper S, Zohar J, Souery D, Montgomery S, Albani D, Forloni G, Ferentinos P, Rujescu D, Mendlewicz J, Colombo R, De Ronchi D, Serretti A, Crisafulli C (2021) Research Domain Criteria (RDoC): A Perspective to Probe the Biological Background behind Treatment Efficacy in Depression Curr Med Chem, 28 (22): 4296-4320
| Weblink | - Dodd S, Bauer M, Carvalho A, Eyre H, Fava M, Kasper S, Kennedy S, Khoo J, Lopez Jaramillo C, Malhi G, McIntyre R, Mitchell P, Castro A, Ratheesh A, Severus E, Suppes T, Trivedi M, Thase M, Yatham L, Young A, Berk M (2021) A clinical approach to treatment resistance in depressed patients: What to do when the usual treatments don’t work well enough? World J Biol Psychiatry, 22 (7): 483-494
| Weblink | - Kasper S, Cubała W, Fagiolini A, Ramos-Quiroga J, Souery D, Young A (2021) Practical recommendations for the management of treatment-resistant depression with esketamine nasal spray therapy: Basic science, evidence-based knowledge and expert guidance World J Biol Psychiatry,
| Weblink | - Zecca L, Pifl C, Fahn S, Sulzer D, Fariello R (2021) Oleh Hornykiewicz, a giant in the understanding and treatment of Parkinson disease npj Parkinson's Disease, 7 (1)
2021 Book Chapters
- Sachs G, Kasper S, Anditsch M, Erfurth A, Lehofer M, Marksteiner J, Rados C, Rujescu D, Sperner-Unterweger B (2021) Was in der Praxis zählt. Diagnostik und Therapie der generalisierten Angststörung. In: , Jatros Neurologie & Psychiatrie Universimed: 2-6
- Graf I, Willeit M, Kasper S, Praschak-Rieder (2021) The Impact of Genetic Polymorphisms on Neuroreceptor Binding: Results from PET and SPECT Neuroreceptor Imaging Studies. In: Dierckx RAJO, Otte A, de Vries EFJ, van Waarde A, Lammertsma AA (Hrsg.) PET and SPECT of Neurobiological Systems. . In: , Springer Nature Springer: 153-190
- Dajić I, Praschak-Rieder N, Lanzenberger R, Spindelegger C, Kasper S, Willeit M (2021) Neuroimaging in Seasons and Winter Depression. In: Rudi A.J.O. Dierckx, Andreas Otte, Erik F. J. de Vries, Aren van Waarde, Iris E. Sommer, PET and SPECT in Psychiatry, Vol.2 Springer International Publishing: 245-259
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2020 Original Articles
- Beiersdorf J, Hevesi Z, Calvigioni D, Pyszkowski J, Romanov RA, Szodorai E, Lubec G, Shirran S, Botting CH, Kasper S, Guy GW, Gray R, Di Marzo V, Harkany T, Keimpema E (2020) Adverse effects of tetrahydrocannabinol on neuronal bioenergetics during postnatal brain development. JCI Insight, 5: e135418
| Weblink | - Calabrò M, Porcelli S, Crisafulli C, Albani D, Kasper S, Zohar J, Souery D, Montgomery S, Mantovani V, Mendlewicz J, Bonassi S, Vieta E, Frustaci A, Ducci G, Landi S, Boccia S, Bellomo A, Di Nicola M, Janiri L, Colombo R, Mandelli L, Fabbri C, Serretti A (2020) Genetic variants associated with psychotic symptoms across disorders psychotic symptoms. Neurosci Lett, 720: 134754
| Weblink | - Spurny B, Seiger R, Moser P, Vanicek T, Reed M, Heckova E, Michenthaler P, Basaran A, Gryglewski G, Klöbl M, Trattnig S, Kasper S, Bogner W, Lanzenberger R (2020) Hippocampal GABA levels correlate with retrieval performance in an associative learning paradigm Neuroimage, 204: 116244
| Weblink | - Friedrich ME, Winkler D, Konstantinidis A, Huf W, Engel RR, Toto S, Grohmann R, Kasper S (2020) Cardiovascular adverse reactions during antipsychotic treatment: Results of AMSP- A drug surveillance program between 1993 and 2013. Int. J. Neuropsychopharmacol., 23: 67-75
- Gryglewski G, Seiger R, Baldinger-Melich P, Unterholzner J, Spurny B, Vanicek T, Hahn, Kasper S, Frey R, Lanzenberger R (2020) Changes in white matter microstructure after electroconvulsive therapy in treatment resistant depression Int J Neuropsychopharmacol, 23: 20-25
| Weblink | - Orthofer M, Valsesia A, Mägi R, Wang Q, Kaczanowska J, Kozieradzki I, Leopoldi A, Cikes D, Zopf L, Tretiakov E, Demetz E, Hilbe R, Boehm A, Ticevic M, Nõukas M, Jais A, Spirk K, Clark T, Amann S, Lepamets M, Neumayr C, Arnold C, Dou Z, Kuhn V, Novatchkova M, Cronin S, Tietge U, Müller S, Pospisilik J, Nagy V, Hui C, Lazovic J, Esterbauer H, Hagelkruys A, Tancevski I, Kiefer F, Harkany T, Haubensak W, Neely G, Metspalu A, Hager J, Gheldof N, Penninger J (2020) Identification of ALK in Thinness Cell, 181 (6): 1246-1262.e22
| Weblink | - Stagkourakis S, Smiley K, Williams P, Kakadellis S, Ziegler K, Bakker J, Brown R, Harkany T, Grattan D, Broberger C (2020) A Neuro-hormonal Circuit for Paternal Behavior Controlled by a Hypothalamic Network Oscillation Cell, 182 (4): 960-975.e15
- Seifritz E, Möller H, Volz H, Müller W, Hopyan T, Wacker A, Schläfke S, Kasper S (2020) No Abuse Potential of Silexan in Healthy Recreational Drug Users: A Randomized Controlled Trial Int J Neuropsychopharmacol, 24 (3): 171-180
| Weblink | - Kasper S, Möller H, Engberg G, Eriksson E, Hökfelt T (2020) Torgny Svensson, a superb mind and an inspiring colleague Int J Neuropsychopharmacol, 23 (8): 543-544
| Weblink | - Komorowski A, Weidenauer A, Murgaš M, Sauerzopf U, Wadsak W, Mitterhauser M, Bauer M, Hacker M, Praschak-Rieder N, Kasper S, Lanzenberger R, Willeit M (2020) Association of dopamine D2/3 receptor binding potential measured using PET and [11C]-(+)-PHNO with post-mortem DRD2/3 gene expression in the human brain Neuroimage, 223: 117270
| Weblink | - Dold M, Bartova L, Kasper S (2020) Treatment Response of Add-On Esketamine Nasal Spray in Resistant Major Depression in Relation to Add-On Second-Generation Antipsychotic Treatment Int J Neuropsychopharmacol, 23 (7): 440-445
| Weblink | - Fugger G, Dold M, Bartova L, Mitschek M, Souery D, Mendlewicz J, Serretti A, Zohar J, Montgomery S, Fabbri C, Frey R, Kasper S (2020) Clinical Correlates and Outcome of Major Depressive Disorder and Comorbid Migraine: A Report of the European Group for the Study of Resistant Depression Int J Neuropsychopharmacol, 23 (9): 571-577
| Weblink | - Cinquina V, Calvigioni D, Farlik M, Halbritter F, Gernedl V, Shirran SL, Fuszard MA, Botting CH, Poullet P, Piscitelli F, Máté Z, Szabó G, Yanagawa Y, Kasper S, Di Marzo V, Mackie K, McBain CJ, Bock C, Keimpema E, Harkany T (2020) Life-long epigenetic programming of cortical architecture by maternal ‘Western’ diet during pregnancy Mol Psychiatry, 25 (1): 22-36
| Weblink | - Fagiolini A, Albert U, Ferrando L, Herman E, Muntean C, Pálová E, Cattaneo A, Comandini A, Di Dato G, Di Loreto G, Olivieri L, Salvatori E, Tongiani S, Kasper S (2020) A randomized, double-blind study comparing the efficacy and safety of trazodone once-a-day and venlafaxine extended-release for the treatment of patients with major depressive disorder Int Clin Psychopharmacol, 35 (3): 137-146
| Weblink | - Dold M, Bartova L, Fugger G, Mitschek M, Kautzky A, Frey R, Montgomery S, Zohar J, Mendlewicz J, Souery D, Fabbri C, Serretti A, Kasper S (2020) Add-on benzodiazepine treatment in patients with major depressive disorder – results from a European cross-sectional multicenter study Eur Neuropsychopharmacol, 41: 70-80
| Weblink | - Fabbri C, Kasper S, Kautzky A, Zohar J, Souery D, Montgomery S, Albani D, Forloni G, Ferentinos P, Rujescu D, Mendlewicz J, Uher R, Lewis C, Serretti A (2020) A polygenic predictor of treatment-resistant depression using whole exome sequencing and genome-wide genotyping Transl Psychiat, 10 (1): 50
| Weblink | - Krivanek J, Soldatov R, Kastriti M, Chontorotzea T, Herdina A, Petersen J, Szarowska B, Landova M, Matejova V, Holla L, Kuchler U, Zdrilic I, Vijaykumar A, Balic A, Marangoni P, Klein O, Neves V, Yianni V, Sharpe P, Harkany T, Metscher B, Bajénoff M, Mina M, Fried K, Kharchenko P, Adameyko I (2020) Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth Nat Commun, 11 (1): 4816
- Pifl C, Sitte H (2020) A Tribute to Oleh Hornykiewicz (1926–2020) Trends Pharmacol Sci, 41 (8): 499-501
- Romanov R, Tretiakov E, Kastriti M, Zupancic M, Häring M, Korchynska S, Popadin K, Benevento M, Rebernik P, Lallemend F, Nishimori K, Clotman F, Andrews W, Parnavelas J, Farlik M, Bock C, Adameyko I, Hökfelt T, Keimpema E, Harkany T (2020) Molecular design of hypothalamus development Nature, 582(7811): 246-252
2020 Reviews
- Keimpema E, Harkany T, Alpár A (2020) The p(l)ot thickens: cannabinoid receptors on astroglial mitochondria coordinate animal behaviors by regulating lactate availability for neurons Signal Transduct Target Ther, 5 (1)
- Fountoulakis KN, Young A, Yatham L, Grunze H, Vieta E, Tohen M, Blier P, Moeller HJ, Kasper S (2020) The CINP guidelines on the definition and the evidence-based interventions for treatment-resistant Bipolar disorder. Invited Review. Int. J. Neuropsychopharmacol., 23: 230-256
| Weblink | - Bartova L, Mitschek MMM, Kasper S (2020) Das aktuelle Verständnis der sogenannten behandlungsresistenten Depression Jatros Neurologie & Psychiatrie , 06/2020: 44-49
- Kasper S, Bancher C, Eckert A, Förstl H, Frölich L, Hort J, Korczyn A, Kressig R, Levin O, Palomo M (2020) Management of mild cognitive impairment (MCI): The need for national and international guidelines World J Biol Psychiatry, 21 (8): 579-594
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2020 Book Chapters
- Silberbauer L, James G, Spies M, Michenthaler P, Kranz GS, Kasper S, Lanzenberger R (2020) Molecular neuroimaging of the serotonergic system with PET. In: , Handbook of the Behavioral Neurobiology of Serotonin Elsevier: 175-194
2019 Original Articles
- Daba Feyissa D, Sialana F, Keimpema E, Kalaba P, Paunkov A, Engidawork E, Höger H, Lubec G, Korz V (2019) Dopamine type 1- and 2-like signaling in the modulation of spatial reference learning and memory Behav Brain Res, 362: 173-180
- Korchynska S, Lutz M, Borók E, Pammer J, Cinquina V, Fedirko N, Irving A, Mackie K, Harkany T, Keimpema E (2019) GPR55 controls functional differentiation of self-renewing epithelial progenitors for salivation JCI Insight, 4 (4)
- Moeller HJ, Volz HP, Dienel A, Schlaefke S, Kasper S (2019) Efficacy of Silexan in subthreshold anxiety: meta‑analysis of randomised, placebo‑controlled trials Eur Arch Psychiatry Clin Neurosci,
- Möller HJ, Volz HP, Dienel A, Schläfke S, Kasper S (2019) Efficacy of Silexan in subthreshold anxiety: meta‑analysis of randomised, placebo‑controlled trials. Eur Arch Psychiatry Clin Neurosci, 269: 183-193
- Möller HJ, Volz HP, Dienel A, Schläfke S, Kasper S (2019) Efficacy of Silexan in subthreshold anxiety: meta‑analysis of randomised, placebo‑controlled trials. Eur Arch Psychiatry Clin Neurosci, 269: 183-193
| Weblink | - Möller HJ, Volz HP, Dienel A, Schläfke S, Kasper S (2019) Efficacy of Silexan in subthreshold anxiety: meta‑analysis of randomised, placebo‑controlled trials. Eur Arch Psychiatry Clin Neurosci, 269: 183-193
| Weblink | - Möller HJ, Volz HP, Dienel A, Schläfke S, Kasper S (2019) Efficacy of Silexan in subthreshold anxiety: meta‑analysis of randomised, placebo‑controlled trials. Eur Arch Psychiatry Clin Neurosci, 260: 183-193
| Weblink | - Möller HJ, Volz HP, Dienel A, Schläfke S, Kasper S (2019) Efficacy of Silexan in subthreshold anxiety: meta‑analysis of randomised, placebo‑controlled trials. Eur Arch Psychiatry Clin Neurosci, 260: 183-193
| Weblink | - Möller HJ, Volz HP, Dienel A, Schläfke S, Kasper S (2019) Efficacy of Silexan in subthreshold anxiety: meta‑analysis of randomised, placebo‑controlled trials. Eur Arch Psychiatry Clin Neurosci, 269: 183-193
| Weblink | - Möller HJ, Volz HP, Dienel A, Schläfke S, Kasper S (2019) Efficacy of Silexan in subthreshold anxiety: meta‑analysis of randomised, placebo‑controlled trials. European Archives of Psychiatry and Clinical Neuroscience , 269: 183-193
| Weblink | - Möller HJ, Volz HP, Dienel A, Schläfke S, Kasper S (2019) Efficacy of Silexan in subthreshold anxiety: meta‑analysis of randomised, placebo‑controlled trials. European Archives of Psychiatry and Clinical Neuroscience , 269: 183-193
| Weblink | - Möller HJ, Volz HP, Dienel A, Schläfke S, Kasper S (2019) Efficacy of Silexan in subthreshold anxiety: meta‑analysis of randomised, placebo‑controlled trials. European Archives of Psychiatry and Clinical Neuroscience , 269: 183-180
| Weblink | - Möller HJ, Volz HP, Dienel A, Schläfke S, Kasper S (2019) Efficacy of Silexan in subthreshold anxiety: meta‑analysis of randomised, placebo‑controlled trials. Eur Arch Psychiatry Clin Neurosci, 269: 183-180
| Weblink | - Müller WE, Eckert A, Eckert G, Fink H, Friedland K, Gauthier S, Hoerr R, Ihl R, Kasper S, Möller HJ (2019) Therapeutic efficacy of the Ginkgo special extract EGb761® within the framework of the mitochondrial cascade hypothesis of Alzheimer’s disease. World J Biol Psychiatry, 20: 173-189
| Weblink | - Meyer BM, Rabl U, Huemer J, Bartova L, Kalcher K, Provenzano J, Brandner C, Sezen P, Kasper S, Schatzberg AF, Moser E, Chen G, Pezawas L (2019) Prefrontal Networks Dynamically Related to Recovery from Major Depressive Disorder: a Longitudinal Pharmacological fMRI Study. Transl Psychiat, 9: 46
| Weblink | - Kalaba P, Ilić M, Aher N, Dragačević V, Wieder M, Zehl M, Wackerlig J, Beyl S, Sartori S, Ebner K, Roller A, Lukic N, Beryozkina T, Gonzalez E, Neill P, Khan J, Bakulev V, Leban J, Hering S, Pifl C, Singewald N, Lubec J, Urban E, Sitte H, Langer T, Lubec G (2019) Structure–Activity Relationships of Novel Thiazole-Based Modafinil Analogues Acting at Monoamine Transporters J Med Chem, 63 (1): 391-417
- Abdo H, Calvo-Enrique L, Lopez J, Song J, Zhang M, Usoskin D, El Manira A, Adameyko I, Hjerling-Leffler J, Ernfors P (2019) Specialized cutaneous Schwann cells initiate pain sensation Science, 365 (6454): 695-699
- Hörtnagl H, Pifl C, Hörtnagl E, Reiner A, Sperk G (2019) Distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the human brain J Neurochem, 152 (6): 650-662
- Tesařová M, Heude E, Comai G, Zikmund T, Kaucká M, Adameyko I, Tajbakhsh S, Kaiser J (2019) An interactive and intuitive visualisation method for X-ray computed tomography data of biological samples in 3D Portable Document Format Sci Rep, 9 (1)
- Dorninger F, König T, Scholze P, Berger M, Zeitler G, Wiesinger C, Gundacker A, Pollak D, Huck S, Just W, Forss-Petter S, Pifl C, Berger J (2019) Disturbed Neurotransmitter Homeostasis in Ether Lipid Deficiency Hum Mol Genet, 28(12): 2046-2061
2019 Reviews
- Kaucka M, Adameyko I (2019) Evolution and development of the cartilaginous skull: From a lancelet towards a human face Semin Cell Dev Biol, 91: 2-12
- Pifl C (2019) The Time Delay Between In Vivo Imaging and Postmortem Data Poses a Caveat on “No Link” Findings Movement Disorders, 34: 1579-1580
2018 Original Articles
- Tesařová M, Mancini L, Simon A, Adameyko I, Kaucká M, Elewa A, Lanzafame G, Zhang Y, Kalasová D, Szarowská B, Zikmund T, Novotná M, Kaiser J (2018) A quantitative analysis of 3D-cell distribution in regenerative muscle-skeletal system with synchrotron X-ray computed microtomography Sci Rep, 8 (1)
- Alpár A, Zahola P, Hanics J, Hevesi Z, Korchynska S, Benevento M, Pifl C, Zachar G, Perugini J, Severi I, Leitgeb P, Bakker J, Miklosi AG, Tretiakov E, Keimpema E, Arque G, Tasan RO, Sperk G, Malenczyk K, Máté Z, Erdélyi F, Szabó G, Lubec G, Palkovits M, Giordano A, Hökfelt TG, Romanov RA, Horvath TL, Harkany T. (2018) Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress EMBO J., 37: e100087
- Maier J, Mayer FP, Luethi D, Holy M, Jaentsch K, Reither H, Hirtler L, Hoener MC, Liechti ME, Pifl C, Brandt SD, Sitte HH (2018) The psychostimulant (±)-cis-4,4′-dimethylaminorex (4,4′-DMAR) interacts with human plasmalemmal and vesicular monoamine transporters Neuropharmacology, 138: 282-291
- Treven M, Siebert D, Holzinger R, Bampali K, Fabjan J, Varagic Z, Wimmer L, Steudle F, Scholze P, Schnürch M, Mihovilovic M, Ernst M (2018) Towards Functional Selectivity for α6β3γ2 GABAA Receptors: A Series of Novel Pyrazoloquinolinones Br J Pharmacol, 175 (3): 419-428
2017 Original Articles
- Milenkovic I, Stojanovic T, Aronica E, Fülöp L, Bozsó Z, Máté Z, Yanagawa Y, Adle-Biassette H, Lubec G, Szabó G, Harkany T, Kovács G, Keimpema E (2017) GABAA receptor subunit deregulation in the hippocampus of human foetuses with Down syndrome Brain Struct Funct,
- Romanov R, Zeisel A, Bakker J, Girach F, Hellysaz A, Tomer R, Alpár A, Mulder J, Clotman F, Keimpema E, Hsueh B, Crow A, Martens H, Schwindling C, Calvigioni D, Bains J, Máté Z, Szabó G, Yanagawa Y, Zhang M, Rendeiro A, Farlik M, Uhlén M, Wulff P, Bock C, Broberger C, Deisseroth K, Hökfelt T, Linnarsson S, Horvath T, Harkany T (2017) Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes Nature Neurosci, 20 (2): 176-188
- Kaucka M, Zikmund T, Tesarova M, Gyllborg D, Hellander A, Jaros J, Kaiser J, Petersen J, Szarowska B, Newton P, Dyachuk V, Li L, Qian H, Johansson A, Mishina Y, Currie J, Tanaka E, Erickson A, Dudley A, Brismar H, Southam P, Coen E, Chen M, Weinstein L, Hampl A, Arenas E, Chagin A, Fried K, Adameyko I (2017) Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage eLife, 6
- Furlan A, Dyachuk V, Kastriti M, Calvo-Enrique L, Abdo H, Hadjab S, Chontorotzea T, Akkuratova N, Usoskin D, Kamenev D, Petersen J, Sunadome K, Memic F, Marklund U, Fried K, Topilko P, Lallemend F, Kharchenko P, Ernfors P, Adameyko I (2017) Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla Science, 357 (6346): eaal3753
- Hornykiewicz O (2017) L-DOPA J Parkinson Dis, 7 (s1): S3-S10
- Tong J, Rathitharan G, Meyer JH, Furukawa Y, Ang LC, Boileau I, Guttman M, Hornykiewicz O, Kish SJ (2017) Brain monoamine oxidase B and A in human parkinsonian dopamine deficiency disorders Brain, 140: 2460-2474
- Ghafari M, Falsafi S, Szodorai E, Kim E, Li L, Höger H, Berger J, Fuchs K, Sieghart W, Lubec G (2017) Formation of GABAA receptor complexes containing α1 and α5 subunits is paralleling a multiple T-maze learning task in mice Brain Struct Funct, 222 (1): 549-561
- Pifl C, Reither H, Lopez-Gonzalez del Rey N, Cavada C, Obeso JA, Blesa J (2017) Early paradoxical increase of dopamine: A neurochemical study of olfactory bulb in asymptomatic and symptomatic MPTP treated monkeys Front Neuroanat, 11: 46
- Rivetti di Val Cervo P, Romanov RA, Spigolon G, Masini D, Martín-Montañez E, Toledo EM, La Manno G, Feyder M, Pifl C, Ng YH, Sánchez SP, Linnarsson S, Wernig M, Harkany T, Fisone G, Arenas E (2017) Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model Nat Biotechnol, 35: 444-452
2017 Reviews
- Kasper S (2017) Phythotherapeutika bei Depression und Angst. Hilfe aus dem Pflanzenreich. Interview Jatros Neurologie & Psychiatrie , 06/2017: 39-40
- Krivanek J, Adameyko I, Fried K (2017) Heterogeneity and Developmental Connections between Cell Types Inhabiting Teeth Front Physiol, 8
- Kastriti M, Adameyko I (2017) Specification, plasticity and evolutionary origin of peripheral glial cells Curr Opin Neurobiol, 47: 196-202
2016 Original Articles
- Calvigioni D, Máté Z, Fuzik J, Girach F, Zhang M, Varro A, Beiersdorf J, Schwindling C, Yanagawa Y, Dockray G, McBain C, Hökfelt T, Szabó G, Keimpema E, Harkany T (2016) Functional Differentiation of Cholecystokinin-Containing Interneurons Destined for the Cerebral Cortex Cereb. Cortex, : bhw094
- Li L, Newton P, Bouderlique T, Sejnohova M, Zikmund T, Kozhemyakina E, Xie M, Krivanek J, Kaiser J, Qian H, Dyachuk V, Lassar A, Warman M, Barenius B, Adameyko I, Chagin A (2016) Superficial cells are self‐renewing chondrocyte progenitors, which form the articular cartilage in juvenile mice FASEB J, 31 (3): 1067-1084
- Hoerbelt P, Ramerstorfer J, Ernst M, Sieghart W, Thomson JL, Hough LB, Fleck MW (2016) Mutagenesis and computational docking studies support the existence of a histamine binding site at the extracellular b3+b3- interface of homooligomeric b3 GABA-A receptors Neuropharmacology, 108: 252-263
- Jonas O, Calligaris D, Methuku K, Poe M, Francois J, Tranghese F, Changelian A, Sieghart W, Ernst M, Pomeranz Krummel D, Cook J, Pomeroy S, Cima M, Agar N, Langer R, Sengupta S (2016) First In Vivo Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development J Biomed Nanotech, 12 (6): 1297-1302
- Pifl C (2016) Problems with traffic ahead: Synaptic vesicles in Parkinson's disease Movement Disorders, 31: 1480
- Sitte HH, Pifl C, Rajput AH, Hörtnagl H, Tong J, Lloyd GK, Kish SJ, Hornykiewicz O (2016) Dopamine and noradrenaline, but not serotonin, in the human claustrum are greatly reduced in patients with Parkinson's disease: possible functional implications Eur J Neurosci, 45: 192-197
- Furukawa Y, Rajput A, Tong J, Tomizawa Y, Hornykiewicz O, Kish S (2016) A marked contrast between serotonergic and dopaminergic changes in dopa-responsive dystonia: Table Neurology, 87 (10): 1060-1061
- Kaucka M, Ivashkin E, Gyllborg D, Zikmund T, Tesarova M, Kaiser J, Xie M, Petersen J, Pachnis V, Nicolis S, Yu T, Sharpe P, Arenas E, Brismar H, Blom H, Clevers H, Suter U, Chagin A, Fried K, Hellander A, Adameyko I (2016) Analysis of neural crest-derived clones reveals novel aspects of facial development Sci Adv, 2 (8): e1600060-e1600060
| Article (PDF) || Weblink | - Marques S, Zeisel A, Codeluppi S, van Bruggen D, Mendanha Falcao A, Xiao L, Li H, Haring M, Hochgerner H, Romanov R, Gyllborg D, Munoz-Manchado A, La Manno G, Lonnerberg P, Floriddia E, Rezayee F, Ernfors P, Arenas E, Hjerling-Leffler J, Harkany T, Richardson W, Linnarsson S, Castelo-Branco G (2016) Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system Science, 352 (6291): 1326-1329
| Article (PDF) || Weblink | - Peneder T, Bauer J, Pifl C (2016) Apoptosis-inducing factor in nigral dopamine neurons: Higher levels in primates than in mice Movement Disorders, 31: 1729-1733
- Zhang MD, Barde S, Szodorai E, Josephson A, Mitsios N, Watanabe M, Attems J, Lubec G, Kovacs GM, Uhlen M, Mulder J, Harkany T, Hökfelt T (2016) Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord Brain Struct Funct, 221 (7): 3803-3823
| Article (PDF) || Weblink | - Berger ML (2016) Soaping the NMDA receptor: Various types of detergents influence differently [³H]MK-801 binding to rat brain membranes Biochim Biophys Acta, 1858: 116-122
2016 Reviews
- Kaucka M, Adameyko I (2016) Spotlight on the Schwann cells during the regeneration Stem Cell Investig, 3: 74-74
- Adameyko I (2016) Neural circuitry gets rewired Science, 354 (6314): 833-834
- Adameyko I, Fried K (2016) The Nervous System Orchestrates and Integrates Craniofacial Development: A Review Front Physiol, 7
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2015 Original Articles
- Pangratz-Fuehrer S, Sieghart W, Rudolph U, Parada I, Huguenard J (2015) Early postnatal switch in GABAAreceptor α-subunits in the reticular thalamic nucleus J. Neurophysiol., 115 (3): 1183-1195
- Ernst M, Sieghart W (2015) GABAA – Rezeptorsubtypen: Strukturelle Vielfalt gibt Hoffnung auf neue Therapiekonzepte Neuroforum, 21 (4): 144-151
- Ernst M, Sieghart W (2015) GABAA receptor subtypes: structural variety raises hope for new therapy concepts e-Neuroforum, 6 (4): 97-103
- Kudryavtsev D, Shelukhina I, Son L, Ojomoko L, Kryukova E, Lyukmanova E, Zhmak M, Dolgikh D, Ivanov I, Kasheverov I, Starkov V, Ramerstorfer J, Sieghart W, Tsetlin V, Utkin Y (2015) Neurotoxins from Snake Venoms and α-Conotoxin ImI Inhibit Functionally Active Ionotropic γ-Aminobutyric Acid (GABA) Receptors J Biol Chem, 290 (37): 22747-22758
- Sieghart W (2015) Allosteric Modulation of GABAA Receptors via Multiple Drug-Binding Sites Adv Pharmacol, : 53-96
- Rycek L, Puthenkalam R, Schnürch M, Ernst M, Mihovilovic M (2015) Metal-assisted synthesis of unsymmetrical magnolol and honokiol analogs and their biological assessment as GABAA receptor ligands Bioorg Med Chem Lett, 25 (2): 400-403
- Yocum GT, Gallos G, Zhang Y, Jahan R, Stephen MR, Varagic Z, Puthenkalam R, Ernst M, Cook JM, Emala CW (2015) Targeting the GABAA Receptor α4 Subunit in Airway Smooth Muscle to Alleviate Bronchoconstriction Am J Respir Cell Mol Biol, Sept 25: Epub ahead of print
- Ádori C, Glück L, Barde S, Yoshitake T, Kovacs G, Mulder J, Maglóczky Z, Havas L, Bölcskei K, Mitsios N, Uhlén M, Szolcsányi J, Kehr J, Rönnbäck A, Schwartz T, Rehfeld J, Harkany T, Palkovits M, Schulz S, Hökfelt T (2015) Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer’s disease Acta Neuropathol, 129 (4): 541-563
- Guggenhuber S, Alpar A, Chen R, Schmitz N, Wickert M, Mattheus T, Harasta AE, Purrio M, Kaiser N, Elphick MR, Monory K, Kilb W, Luhmann HJ, Harkany T, Lutz B, Klugmann M (2015) Cannabinoid receptor-interacting protein Crip 1a modulates CB1 receptor signaling in mouse hippocampus Brain Struct Funct, March 15: Epub ahead of print
- Penz O, Fuzik J, Kurek A, Romanov R, Larson J, Park T, Harkany T, Keimpema E (2015) Protracted brain development in a rodent model of extreme longevity Sci Rep, 5: 11592
| Article (PDF): 1 2 | - Valladolid-Acebes I, Daraio T, Brismar K, Harkany T, Ögren S, Hökfelt T, Bark C (2015) Replacing SNAP-25b with SNAP-25a expression results in metabolic disease PNAS, 112 (31): E4326-E4335
- Bitencourt R, Alpár A, Cinquina V, Ferreira S, Pinheiro B, Lemos C, Ledent C, Takahashi R, Sialana F, Lubec G, Cunha R, Harkany T, Köfalvi A (2015) Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents Neurochem Internat, 90: 72-84
- Malenczyk K, Keimpema E, Piscitelli F, Calvigioni D, Björklund P, Mackie K, Di Marzo V, Hökfelt T, Dobrzyn A, Harkany T (2015) Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture PNAS, 112 (45): E6185-E6194
- Alpár A, Di Marzo V, Harkany T (2015) At the Tip of an Iceberg: Prenatal Marijuana and Its Possible Relation to Neuropsychiatric Outcome in the Offspring Biol Psychiatry,
- Tesoriero C, Codita A, Zhang M, Cherninsky A, Karlsson H, Grassi-Zucconi G, Bertini G, Harkany T, Ljungberg K, Liljeström P, Hökfelt T, Bentivoglio M, Kristensson K (2015) H1N1 influenza virus induces narcolepsy-like sleep disruption and targets sleep–wake regulatory neurons in mice PNAS, 113 (3): E368-E377
- Fuzik J, Zeisel A, Máté Z, Calvigioni D, Yanagawa Y, Szabó G, Linnarsson S, Harkany T (2015) Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes Nat Biotechnol, 34 (2): 175-183
- Ivashkin E, Khabarova M, Melnikova V, Nezlin LP, Kharchenko O, Voronezhskaya EE, Adameyko I (2015) Serotonin Mediates Maternal Effects and Directs Developmental and Behavioral Changes in the Progeny of Snails Cell Rep, 12 (7): 1144-1158
| Article (PDF) || Weblink | - Hnat J, Berger ML (2015) Radioligand kinetics at the NMDA receptor channel revisited: an active part by Na+ and Tris Neurotransmitter, 2: e 945
- Hornykiewicz O (2015) 50 years of levodopa Movement Disorders, 30: 1008
- Tong J, Ang LC, Williams B, Furukawa Y, Fitzmaurice P, Guttman M, Boileau I, Hornykiewicz O, Kish SJ (2015) Low levels of astroglial markers in Parkinson's disease: relationship to alpha-synuclein accumulation Neurobiol Dis, 82: 243-253
- Berger ML, Rebernik P (2015) Differential influence of 7 cations on 16 non-competitive NMDA receptor blockers Bioorg Med Chem Lett, 25 (19): 4131-4135
| Article (PDF) || Weblink | - Karabacak Y, Sase S, Aher YD, Sase A, Saroja SR, Cicvaric A, Höger H, Berger M, Bakulev V, Sitte HH, Leban J, Monje FJ, Lubec G (2015) The effect of modafinil on the rat dopamine transporter and dopamine receptors D1-D3 paralleling cognitive enhancement in the radial arm maze Front Behav Neurosci, Epub August 2015
- Ramerstorfer J, Foppa V, Thiery H, Hermange P, Janody S, Berger M, Dodd R, Sieghart W (2015) GABAA Receptor Subtype-Selectivity of Novel Bicuculline Derivates Curr Med Chem, 22: 771-780
- Berger M, Maciejewska D, Vanden Eynde JJ, Mottamal M, Zabinski J, Kazmierczak P, Rezler M, Jarak I, Piantanida I, Karminski-Zamola G, Mayence A, Rebernik P, Kumar A, Ismail MA, Boykin DW, Huang TL (2015) Pentamidine analogs as iInhibitors of [3H]MK-801 and [3H]ifenprodil binding to rat brain NMDA receptors Bioorg Med Chem, 23 (15): 4489-4500
| Article (PDF): 1 2 || Weblink | - Pifl C, Reither H, Hornykiewicz O (2015) The profile of mephedrone on human monoamine transporters differs from 3,4-methylenedioxymethamphetamine primarily by lower potency at the vesicular monoamine transporter Eur J Pharmacol, 755: 119-126
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2014 Original Articles
- Keimpema E, Zheng K, Barde SS, Berghuis P, Dobszay MB, Schnell R, Mulder J, Luiten PG, Xu ZD, Runesson J, Langel Ü, Lu B, Hökfelt T, Harkany T (2014) GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain Cereb. Cortex,
- Dyachuk V, Furlan A, Shahidi M, Giovenco M, Kaukua N, Konstantinidou C, Pachnis V, Memic F, Marklund U, Muller T, Birchmeier C, Fried K, Ernfors P, Adameyko I (2014) Parasympathetic neurons originate from nerve-associated peripheral glial progenitors Science, 345 (6192): 82-87
- Kaukua N, Shahidi M, Konstantinidou C, Dyachuk V, Kaucka M, Furlan A, An Z, Wang L, Hultman I, Ährlund-Richter L, Blom H, Brismar H, Lopes N, Pachnis V, Suter U, Clevers H, Thesleff I, Sharpe P, Ernfors P, Fried K, Adameyko I (2014) Glial origin of mesenchymal stem cells in a tooth model system Nature, 513 (7519): 551-554
- Obradović A, Joksimović S, Poe M, Ramerstorfer J, Varagic Z, Namjoshi O, Batinić B, Radulović T, Marković B, Roth B, Sieghart W, Cook J, Savić M (2014) Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: The approximated activation of receptor subtypes may explain behavioral effects Brain Res, 1554: 36-48
- Middendorp S, Puthenkalam R, Baur R, Ernst M, Sigel E (2014) Accelerated Discovery of Novel Benzodiazepine Ligands by Experiment-Guided Virtual Screening ACS Chem Biol, 9 (8): 1854-1859
- Carta V, Pangerl M, Baur R, Puthenkalam R, Ernst M, Trauner D, Sigel E (2014) A Pentasymmetric Open Channel Blocker for Cys-Loop Receptor Channels PLoS One, 9 (9): e106688
- Iannotti F, Silvestri C, Mazzarella E, Martella A, Calvigioni D, Piscitelli F, Ambrosino P, Petrosino S, Czifra G, Biro T, Harkany T, Taglialatela M, Di Marzo V (2014) The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels PNAS, 111 (24): E2472-E2481
- Parnia S, Spearpoint K, de Vos G, Fenwick P, Goldberg D, Yang J, Zhu J, Baker K, Killingback H, Beisteiner R, Berger M, Bullock S, Sutton J, Walmsley A, Deakin CD, Little P, Farber M, Greyson B, Schoenfeld ER (2014) AWARE-AWAREness during REsuscitation-A prospective study Resuscitation, 85: 1799-1805
- Romanov R, Alpar A, Zhang M, Zeisel A, Calas A, Landry M, Fuszard M, Shirran SL, Schnell R, Dobolyi A, Olah M, Spence L, Mulder J, Martens H, Palkovits M, Uhlen M, Sitte H, Botting CH, Wagner L, Linnarsson S, Hökfelt T, Harkany T (2014) A secretagonin locus of the mammalian hypothalamus controls stress hormon release EMBO J., 34 (1): 36-54
| Article (PDF) | - Maccarrone M, Guzman M, Mackie K, Doherty P, Harkany T (2014) Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies Nat. Rev. Neurosci., 15: 786-801
- Ferreira SG, Goncalves FQ, Marques JM, Tomé AR, Rodrigues RJ, Nunes-Correia I, Ledent C, Harkany T, Venance L, Cunha RA, Köfalvi A (2014) Presynaptic A2A adenosine receptors dampen CB1 cannabinoid receptor-mediated inhibition of corticostriatal glutamatergic transmission Br J Pharmacol, Oct 9
- Harkany T, Zeilhofer HU, Cattaneo A (2014) Neurotrophin and endocannabinoid interactions in the neurobiology of pain Eur J Neurosci, 39: 331-333
- Gati G, Lendvai D, Hökfelt T, Harkany T, Alpar A (2014) Revival of calcium-binding proteins for neuromorphology: secretagonin typifies distinct cell populations in the avian brain Brain Behav Evol, Epub April 24. 2014
- Iannotti FA, Silvestri C, Mazzarella E, Martella A, Calvigioni D, Piscitelli F, Ambrosino P, Petrosino S, Czifra G, Biro T, Harkany T, Taglialatela M, Di Marzo V (2014) The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels Proc Natl Acad Sci USA, Epub June 3, 2014
- Zhang M, Tortoriello G, Hsueh B, Tomer R, Ye L, Mitsios N, Borgius L, Grant G, Kiehn O, Watanabe M, Uhlen M, Mulder J, Deisseroth K, Harkany T, Hökfelt T (2014) Neuronal calcium-binding proteins 1/2 localize to dorsal root ganglia and excitatory spinal neurons and are regulated by nerve injury PNAS, 111 (12): E1149-E1158
- Pifl C, Rajput A, Reither H, Blesa J, Cavada C, Obeso JA, Rajput AH, Hornykiewicz O (2014) Is Parkinson's Disease a Vesicular Dopamine Storage Disorder? Evidence from a Study in Isolated Synaptic Vesicles of Human and Nonhuman Primate Striatum J Neurosci, 24: 8210-8218
- Tortoriello G, Morris CV, Alpar A, Fuzik J, Shirran SL, Calvigioni D, Keimpema E, Botting CH, Reinecke K, Herdegen T, Courtney M, Hurd YL, Harkany T (2014) Miswiring the brain: delta9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway Embo Journ, 33: 668-85
- Mirheydari P, Ramerstorfer J, Varagic Z, Scholze P, Wimmer L, Mihovilovic MM, Sieghart W, Ernst M (2014) Unexpected properties of delta-containing GABA-A receptors in response to ligands interacting with the alpha+beta-site Neurochem Res, 39 (6): 1057-1067
2014 Reviews
- Keimpema E, Hökfelt T, Harkany T, Doherty P (2014) The molecular interplay between endocannabinoid and neurotrophin signals in the nervous system and beyond Eur J Neurosci, 39: 334-343
- Calvigioni D, Hurd YL, Harkany T, Keimpema E, (2014) Neuronal substrates and functional consequences of prenatal cannabis exposure Child Adolesc Psychiatry Ment Health, Epub May 3, 2014
2014 Book Chapters
- Sieghart W (2014) GABA-A receptors in the brain: exciting targets for the development of clinically important drugs. In: , Magyar Tudomanyos Akademia k.A.: k.A.
2013 Original Articles
- Keimpema E, Alpár A, Howell F, Malenczyk K, Hobbs C, Hurd Y, Watanabe M, Sakimura K, Kano M, Doherty P, Harkany T (2013) Diacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signaling Sci Rep, 3 (1)
- Baur R, Kielar M, Richter L, Ernst M, Ecker G, Sigel E (2013) Molecular analysis of the site for 2-arachidonylglycerol (2-AG) on the β 2 subunit of GABA A receptors J Neurochem, 126 (1): 29-36
- Palangsuntikul R, Berner H, Berger ML,Wolschann P (2013) Holographic Quantitative Structure-Activity Relationships of Tryptamine Derivatives at NMDA, 5HT-1A and 5HT-2A Receptors Molecules, 18: 8799-8811
- Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Mimata H, Yoshimura A, Tamir I, Herbst R, Martinez J, Penninger JM et al. (2013) CLP1 links tRNA metabolism to progressive motor-neuron loss Nature, 495 (7442): 474-480
| Weblink | - Keimpema E, Tortoriello G, Alpar A, Capsoni S, Arisi I, Calvigioni D, Hu S, Cattaneo A, Doherty P, Mackie K, Harkany T (2013) Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons PNAS, 110: 1935-1940
- Malenczyk K, Jazurek M, Keimpema E, Silvestri C, Janikiewicz J, Mackie K, Di Marzo V, Redowicz MJ, Harkany T, Dobrzyn A (2013) CB1 Cannabinoid Receptors Couple to Focal Adhesion Kinase to Control Insulin Release J Biol Chem, 288: 32685-32699
- Joksimovic S, Varagic Z, Kovacevic J, Van Linn M, Milic M, Rallapali S, Timic T, Sieghart W, Cook JM, Savic MM (2013) Insights into functional pharmacology of alpha1 GABA-A receptors: how much does partial activation at the benzodiazepine site matter? Psychopharmycol, 230: 113-123
- Yip GM, Chen ZW, Edge CJ, Smith EH, Dickinson R, Hohenester E, Townsend RR, Fuchs K, Sieghart W, Evers AS, Fanks NP (2013) A propofol binding site on mammalian GABA-A receptors identified by photolabeling Nature Chem Biol, 9: 715-720
- Milenkovic I, Vasiljevic M, Maurer D, Höger H, Klausberger T, Sieghart W. (2013) The parvalbumin-positive interneurons in the mouse dentate gyrus express GABAA receptor subunits alpha1, beta2, and delta along their extrasynaptic cell membrane. Neuroscience, 254: 80-96
| Weblink | - Varagic Z, Ramerstorfer J, Huang S, Rallapalli S, Sarto-Jackson I, Cook J, Sieghart W, Ernst M (2013) Subtype selectivity of alpha+beta-site ligands of GABA-A receptors - identification of the first highly specific positive modulators at alpha6beta2/3gamma2 receptors Br J Pharmacol, 169(2): 384-399
- Varagic Z, Wimmer L, Schnuerch M, Mihovilovic MD, Huang S, Rallapalli S, Cook JM, Mirheydari P, Ecker GF, Sieghart W, Ernst M (2013) Identification of novel positive allosteric modulators and null modulators at the GABA-a receptor alpha+beta-interface Br J Pharmacol, 169(2): 371-383
- Hoertnagl H, Tasan RO, Wieselthaler A, Kirchmair E, Sieghart W, Sperk G (2013) Patterns of mRNA and protein expression for 12 GABA-A receptor subunits in the mouse brain Neuroscience, 236: 345-372
- Sieghart W (2013) Anxioselective anxiolytics: additional perspective Trends Pharmacol Sci, 34: 145-146
- Namjoshi OA, Wang Z-J, Rallapalli SK, Johnson EM Jr, Johnson Y-T, Ng H, Ramerstorfer J, Varagic Z, Sieghart W, Majumder S, Roth BL, Rowlett JK, Cook JM (2013) Search for alpha3beta2/3gamma2 subtype selective ligands that are stableon human liver microsomes Bioorg Med Chem, 21: 93-101
- Pifl C, Hornykiewicz O, Blesa J, Adanez R, Cavada C, Obeso JA (2013) Reduced noradrenaline, but not dopamine and serotonin in motor thalamus of the MPTP primate: relation to severity of Parkinsonism J Neurochem, 125: 657-662
- Berger ML, Hammerschmidt F, Qian R, Hahner S, Schirbel A, Stichelberger M, Schibli R, Yu J, Arion VB, Woschek A, Öhler E, Zolle IM (2013) [3H]Metyrapol and 4-[131I]Iodometomidate Label Overlapping, but Not Identical, Binding Sites on Rat Adrenal Membranes Mol Pharmaceutics, 10: 1119-1130
| Article (PDF) | - Mark C, Bornatowicz B, Mitterhauser M, Hendl M, Nics L, Haeusler D, Lanzenberger R, Berger ML, Spreizer H, Wadsak W (2013) Development and automation of a novel NET-PET tracer: [11C]Me@APPI Nucl Med and Biol, 40: 295-303
2013 Reviews
- Keimpema E, Calvigioni D, Harkany T (2013) Endocannabinoid signals in the developmental programming of delayed-onset neuropsychiatric and metabolic illnesses Biochem. Soc. Trans., 41: 1569-1576
2012 Original Articles
- Richter L, de Graaf C, Sieghart W, Varagic Z, Mörzinger M, de Esch IJP, Ecker GF, Ernst M (2012) Diazepam-bound GABA-A receptor models identify new benzodiazepine binding-site ligands Nature Chem Biol, 8: 455-464
- Spurny R, Ramerstorfer J, Price K, Brams M, Ernst M, Nury H, Verheij M, Legrand P, Bertrand D, Bertrand S, Dougherty DA, de Esch IJ, Corringer PJ, Sieghart W, Lummis SC, Ulens C (2012) Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines Proc Natl Acad Sci USA, 109(44): E3028-34
- Berger ML, Pöhler T, Schadt O, Stanger M, Rebernik P, Scholze P, Noe CR (2012) Exploring the Polyamine Regulatory Site of the NMDA Receptor: a Parallel Synthesis Approach ChemMedChem, 8 (1): 82-94
| Article (PDF) || Weblink | - Pifl C, Stephen J, Kish SJ, Hornykiewicz O (2012) Thalamic noradrenaline in Parkinson's disease: Deficits suggest role in motor and non-motor symptoms Movement Disorders, 27: 1618-1624
- Maj M, Milenkovic I, Bauer J, Berggard T, Veit M, Ilhan-Mutlu A, Wagner L, Tretter V (2012) Novel insights into the distribution and functional aspects of the calcium binding protein Secretagogin from studies on rat brain and primary neuronal cell culture Front Mol Neurosci, 5: Article 84
| Supplement | - Berger ML, Palangsuntikul R, Rebernik P, Wolschann P, Berner H (2012) Screening of 64 tryptamines at NMDA, 5-HT1A, and 5-HT2A receptors: a comparative binding and modeling study Curr Med Chem, 19 (18): 3044-3057
| Weblink | - J. Blesa, C. Pifl, M.A. Sánchez-González, C. Juri, M.A. García-Cabezas, R. Adánez, E. Iglesias, M. Collantes, I. Peñuelas, J.J. Sánchez-Hernández, M.C. Rodríguez-Oroz, C. Avendaño, O. Hornykiewicz et (2012) The nigrostriatal system in the presymptomatic and symptomatic stages in the MPTP monkey model: A PET, histological and biochemical study Neurobiol Dis, 48: 79-91
- Chen ZW, Manion B, Townsend RR, Reichert DE, Covey DF, Steinbach JH, Sieghart W, Fuchs K, Evers AS (2012) Neurosteroid analogue photolabeling of a site in the TM3 domain of the beta3 subunit of the GABA-A receptor Mol Pharmacol, 82: 408-419
- Utkin YN, Weise C, Kasheverov IE, Andreeva TV, Kyukova EV, Zhmak MN, Starkov VG, Anh HN, Bertrand D, Ramerstorfer J, Sieghart W, Lummis S, Tsetlin VI (2012) Azemiopsin from Azemiops feae viper venom, a new polypeptide ligand of nicotinic acetylcholine receptor J Biol Chem, 287: 27079-27086
- Joksimovic S, Divljakovic J, Van Linn ML, Varagic Z, Brajkovic G, Milinkovic MM, Yin W, Timic T, Sieghart W, Cook JM, Savic MM (2012) Benzodiazepine-induced spatial learning deficits in rats are regulated by the degree of modulation of a1 GABA-A receptors Eur Neuropsychopharmacol, 23: 390-399
| Supplement | - Seeger C, Christopeit T, Fuchs K, Grote K, Sieghart W, Danielson UH (2012) Histaminergic pharmacology of homo-oligomeric beta3 gamma-aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology Biochem Pharmacol, 84: 341-355
- Radner S, Celie PH, Fuchs K, Sieghart W, Sixma TK, Stornaiuolo M (2012) Transient transfection coupled to baculovirus infection for rapid protein expression screening in insect cells J Struc Biol, 179: 46-55
- Tretter V, Mukherjee J, Maric HM, Schindelin H, Sieghart W, Moss SJ (2012) Gephyrin, the enigmatic organizer at GABAergic synapses Front Cell Neurosci, 6: 1-16
- Sieghart W (2012) Unraveling the role of GABA-A receptor subtypes in distinct neurons and behaviour J Physiol, 590: 2181-2182
- Sarto-Jackson I, Milenkovic I, Smalla K-H, Gundelfinger ED, Kaehne T, Herrera-Molina R, Thomas S, Kiebler MA, Sieghart W (2012) The cell adhesion molecule neuroplastin-65 is a novel interaction partner of gamma-aminobutyric acid type A receptors J Biol Chem, 287: 14201-14214
| Supplement | - Richter L, de Graaf C, Sieghart W, Varagic Z, Mörzinger M, de Esch IJP, Ecker GF, Ernst M (2012) Diazepam-bound GABA-A receptor models identify new benzodiazepine binding site ligands Nature Chem Biol, 8: 455-464
- Sieghart W, Ramerstorfer J, Sarto-Jackson I, Varagic Z, Ernst M (2012) A novel GABA-A receptor pharmacology: drugs interacting with the alpha+beta-interface Br J Pharmacol, 166: 476-485
- Chen ZW, Fuchs K, Sieghart W, Townsend RR, Evers AS (2012) Deep amino acid sequencing of native brain GABA-A receptors using high-resolution mass spectrometry Mol Cell Proteomics, 11.1, 10.1074/mcp.M111.011445-1: Epub Oct 2011
- Vasiljevic M, Heisler FF, Hausrat TJ, Fehr S, Milenkovic I, Kneussel M, Sieghart W (2012) Spatio-temporal expression analysis of the calcium-binding protein calumenin in the rodent brain Neuroscience, 202: 29-41
- Sperk G, Wieselthaler-Hölzl A, Pirker S, Tasan R, Strasser SS, Drexe M, Pifl C, Marschalek J, Ortler M, Trinka E, Haitmair-Wietzorrek K, Ciofi P, Feucht M, Baumgartner C, Czech T (2012) Glutamate decarboxylase67 is expressed in hippocampal mossy fibers of temporal lobe epilepsy patients Hippocampus, 22: 590-603
- Sommerauer C, Rebernik P, Reither H, Nanoff C, Pifl C (2012) The noradrenaline transporter as site of action for the anti-Parkinson drug amantadine. Neuropharmacology, 62 (4): 1708-1716
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2012 Reviews
- Keimpema E, Straiker A, Mackie K, Harkany T, Hjerling‐Leffler J (2012) Sticking out of the crowd: the molecular identity and development of cholecystokinin‐containing basket cells Am J Physiol, 590 (4): 703-714
2011 Original Articles
- Mulder J, Zilberter M, Pasquaré S, Alpár A, Schulte G, Ferreira S, Köfalvi A, Martín-Moreno A, Keimpema E, Tanila H, Watanabe M, Mackie K, Hortobágyi T, de Ceballos M, Harkany T (2011) Molecular reorganization of endocannabinoid signalling in Alzheimer’s disease Brain, 134 (4): 1041-1060
- Yang AR, Liu J, Yi HS, Warnock KT, Wang M, June HL Jr, Puche AC, Elnabawi A, Sieghart W, Aurelian L, June HL Sr (2011) Binge drinking: in search of its molecular target via the GABA-A receptor Front Neurosci, 5:123: Epub Oct 2011
- Leppä E, Linden AM, Vekovischeva OY, Swinny JD, Rantanen V, Toppila E, Höger H, Sieghart W, Wulff P, Wisden W, Korpi ER (2011) Removal of GABA-A receptor gamma2 subunits from parvalbumin neurons causes wide-ranging behavioural alterations PLoS.ONE., 6 (9): e24159
- Shrivastava AN, Triller A, Sieghart W (2011) GABA-A receptors: post-synaptic co-localization and cross-talk with other receptors Front Cell Neurosci, 5,7: Epub June 2011
- Ouattara B, Gregoire L, Morissette M, Gasparini F, Vranesic I, Bilbe G, Johns DR, Rajput A, Hornykiewicz O, Rajput AH, Gomez-Mancilla B, Di PaoloT (2011) Metabotropic glutamate receptor type 5 in levodopa-induced motor complications Neurobiol Aging, 32: 1286-1295
- Tretter V, Kerschner B, Milenkovic I, Ramsden SL, Ramerstorfer J, Saiepour L, Maric HM, Moss SJ, Schindelin H, Harvey RJ, Sieghart W, Harvey K (2011) Molecular basis of the GABA-A receptor alpha3 subunit interaction with the clustering protein gephyrin J Biol Chem, 286 (43): 37702-37711
- Suryanarayanan A, Liang J, Meyer EM, Lindemeyer AK, Chandra D, Homanics GE, Sieghart W, Olsen RW, Spigelman I (2011) Subunit compensation and plasticity of synaptic GABA-A receptors induced by ethanol in alpha4 subunit knockout mice Front Neurosci, 5: Article 110
- Corteen NL, Cole TM, Sarna A, Sieghart W, Swinny JD (2011) Localisation of GABA-A receptor subunits on neurochemically distinct cell-types in the rat locus coeruleus Eur J Neurosci, 34: 260-262
- Shrivastava AN, Triller A, Sieghart W, Sarto-Jackson I (2011) Regulation of GABA-A receptor dynamics by interaction with P2X-2 receptors J Biol Chem, 286: 14455-14468
- Gross A, Sims RE, Swinny JD, Sieghart W, Bolam JP, Stanford IM (2011) Differential localization of GABA-A receptor subunits in relation to striato-pallidal and pallido-pallidal synapses Eur J Neurosci, 33: 868-878
- Liu J, Yang A, Kelly T, Puche A, Esoga C, June H, Jr., Elnabawi A, Merchenthaler I, Sieghart W, June H, Sr., Aurelian L (2011) Binge alcohol drinking is associated with GABA-A alpha2-regulated TLR4 expression in the central amygdala PNAS, 108: 4465-4470
- Shen Y, Lindemeyer KA, Spigelman I, Sieghart W, Olsen RW, Liang J (2011) Plasticity of GABA-A receptors following ethanol pre-exposure in cultured hippocampal neurons Mol Pharmacol, 79: 432-442
- Ramerstorfer J, Furtmüller R, Sarto-Jackson I, Varagic Z, Sieghart W, Ernst M (2011) The GABA-A receptor alpha+beta-interface: a novel target for subtype-selective drugs J Neurosci, 31: 870-877
- Schosser A, Schloegelhofer M, Fuchs K, Stojanovic M, Mossaheb N, Kindler J, Cohen-Woods S, Hosang G, Farmer A, Craig I, McGuffin P, Aschauer H (2011) Bipolar disorder susceptibility region on chromosome 3q29 not confirmed in a case-control association study World J Biol Psychiat, 12: 309-315
- Neuhaus W, Freidl M, Szkokan P, Berger M L, Wirth M, Winkler J, Gabor F, Pifl C, Noe CR (2011) Effects of NMDA receptor modulators on a blood-brain barrier in vitro model Brain Res, 1394: 49-61
- Tong J, Furukawa Y, Sherwin A, Hornykiewicz O, Kish SJ (2011) Heterogeneous intrastriatal pattern of proteins regulating axon growth in normal adult human brain Neurobiol Dis, 41: 458-468
- Peneder TM, Scholze P, Berger ML, Reither H, Heinze G, Bertl J, Bauer J, Richfield EK, Hornykiewicz O, Pifl C (2011) Chronic exposure to manganese decreases striatal dopamine turnover in human alpha-synuclein transgenic mice Neuroscience, 180: 280-292
- Kindler J, Bailer U, De Zwaan M, Fuchs K, Leisch F, Grün B, Strnad A, Stojanovic M, Windisch J, Lennkh-Wolfsberg, El-Giamal N, Sieghart W, Kasper S, Aschauer H (2011) No association of the neuropeptide Y (Leu7Pro) and ghrelin gene (Arg51Gln, Leu72Met, Gln90Leu) single nucleotide polymorphisms with eating disorders Nordic Journal of Psychiatry, 65: 203-207
2011 Reviews
- Keimpema E, Mackie K, Harkany T (2011) Molecular model of cannabis sensitivity in developing neuronal circuits Trends Pharmacol Sci, 32 (9): 551-561
2010 Original Articles
- Keimpema E, Barabas K, Morozov Y, Tortoriello G, Torii M, Cameron G, Yanagawa Y, Watanabe M, Mackie K, Harkany T (2010) Differential Subcellular Recruitment of Monoacylglycerol Lipase Generates Spatial Specificity of 2-Arachidonoyl Glycerol Signaling during Axonal Pathfinding J Neurosci, 30 (42): 13992-14007
- Abramian AM, Comenencia-Ortiz E, Vithlani M, Tretter V, Sieghart W, Davies PA, Moss SJ (2010) Protein kinase C phosphorylation regulates membrane insertion of GABA-A receptor subtypes that mediate tonic inhibition J Biol Chem, 285: 41795-41805
- Hornykiewicz O (2010) A brief history of levodopa J Neurol, 257: S249-S252
- Kasugai Y, Swinny J, Roberts D, Dalezios Y, Fukazawa Y, Sieghart W, Shigemoto R, Somogyi P (2010) Quantitative localisation of synaptic and extrasynaptic GABA-A receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabeling Eur J Neurosci, 32: 1868-1888
- Fischer BD, Licata SC, Edwankar RV, Wang ZJ, Huang S, He X, Yu J, Zhou H, Johnson EM Jr, Cook JM, Furtmüller R, Ramerstorfer J, Sieghart W, Roth BL, Majumder S, Rowlett JK (2010) Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure Neuropharmacology, 59: 612-618
- Savic MM, Majumder S, Huang SM, Edwankar RV, Furtmüller R, Joksimovic S, Clayton T, Ramerstorfer J, Milinkovic MM, Roth BL, Sieghart W, Cook JM (2010) Novel positive allosteric modulators of GABA-A receptors: Do subtle differences in activity at alpha1 plus a5 versus a2 plus a3 subunits account for dissimilarities in behavioural effects in rats? Progr Neuro-Psychopharmacol & Biol Psychiat, 34: 376-386
| Article (PDF) | - Ramerstorfer J, Furtmüller R, Vogel E, Huck S, Sieghart W (2010) The point mutation gamma2F77I changes the potency and efficacy of benzodiazepine site ligands in different GABAA receptor subtypes Eur J Pharmacol, 636: 18-27
| Article (PDF) | - Tong J, Wong H, Guttman M, Ang L, Forno L, Shimadzu M, Rajput A, Muenter M, Kish S, Hornykiewicz O, Furukawa Y (2010) Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson´s disease and progressive supranuclear palsy: a comparative investigation Brain, 133: 172-188
| Article (PDF) | - Schosser A, Fuchs K, Scharl T, Schloegelhofer M, Kindler J, Mossahed N, Kaufmann RM, Leisch F, Kasper S, Sieghart W, Aschauer HN (2010) Interaction between Serotonin 5-HT2A receptor gene and Dopamine Transporter (DAT1) gene polymorphisms influences personality trait of Persistence in Austrian Caucasians World J Biol Psychiat, 11: 417-424
2009 Original Articles
- Keimpema E, Fokkens M, Nagy Z, Agoston V, Luiten P, Nyakas C, Boddeke H, Copray J (2009) Early transient presence of implanted bone marrow stem cells reduces lesion size after cerebral ischaemia in adult rats Neuropathol Appl Neurobiol, 35 (1): 89-102
- Kaufmann R, Kraft B, Frey R, Winkler D, Weiszenbichler S, Bäcker C, Kasper S, Kress H (2009) Acute Psychotropic Effects of Oral Cannabis Extract with a Defined Content of Δ 9 -Tetrahydrocannabinol (THC) in Healthy Volunteers Pharmacopsychiatry, 43 (01): 24-32
- Marchionni I, Kasap Z, Mozrzymas JW, Sieghart W, Cherubini E, Zacchi P (2009) New insights on the role of gephyrin in regulating both phasic and tonic GABAergic inhibitition in rat hippocampal neurons in culture Neuroscience, 164(2): 552 - 562
- de Kovel CGF, Trucks H, Helbig I, Rosenow F, Zimprich F, Urak L, Feucht M, Fuchs K, Schreiber S, Nürnberg P, Eichler E, Sander T (2009) Recurrent microdeletions at 15q11.2 and 16p13.11 predispose to idiopathic generalized epilepsies Brain, 133: 23-32
- Hanada R, Leibbrandt A, Hanada T, Kitaoka S, Furuyashiki T, Fujihara H, Trichereau J, Paolino M, Qadri F, Plehm R, Klaere S, Komnenovic V, Mimata H, Pifl C, Penninger J et al (2009) Central control of fever and female body temperature by RANKL/RANK Nature, 462: 505-509
- Tretter V, Revilla-Sanchez R, Houston C, Terunuma M, Havekes R, Florian C, Jurd R, Vithlani M, Michels G, Couve A, Sieghart W, Brandon N, Abel T, Smart T, Moss S (2009) Deficits in spatial memory correlate with modified y-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus Proc Natl Acad Sci USA, 106: 20039-20044
- Kang SU, Fuchs K, Sieghart W, Pollak A, Csaszar E, Lubec G (2009) Gel-based mass spectrometric analysis of a strongly hydrophobic GABAA-receptor subunit containing four transmembrane domains Nat Protoc, 4: 1093-1102
| Article (PDF) | - Atucha E, Hammerschmidt F, Zolle I, Sieghart W, Berger M L (2009) Structure-activity relationship of etomidate derivatives at the GABA-A receptor: Comparison with binding to 11-beta-hydroxylase Bioorg Med Chem Lett, 19: 4284-4287
| Article (PDF) | - Rivas FM, Stables JP, Murphree L, Edwankar RV, Edwankar CR, Huang S, Jain HD, Zhou H, Majumder S, Sankar S, Roth BL, Ramerstorfer J, Furtmüller R, Sieghart W, Cook JM (2009) Antiseizure activity of novel gamma-aminobutyric acid(A) receptor subtype-selective benzodiazepine analogues in mice and rat models J Med Chem, 52: 1795-1798
| Article (PDF) | - Helbig I, Rosenow F, Urak L, Fuchs K, Feucht M, Franke A, Muhle H, Baker C, Klein KM, Wittig M, Nothnagel M, Schreiber S, Eichler EE, Sander T (2009) 15q13.3 microdeletions increase risk of idiopathic generalized epilepsy Nature Genetics, 41(2): 160-162
- Boileau I, Guttman M, Rusjan P, Adams JR, Houle S, Tong J, Hornykiewicz O, Furukawa Y, Wilson AA, Kapur S, Kish SJ (2009) Decreased binding of the D3 dopamine receptor-preferring ligand [11C]-(+)-PHNO in drug-naive Parkinson´s disease Brain, 132: 1366-1375
| Article (PDF) | - Berger M.L, Schweifer A, Rebernik P, Hammerschmidt F (2009) NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds Bioorg Med Chem, 17: 3456-3462
| Article (PDF) | - Samadi P, Rajput A, Calon F, Gregoire L, Hornykiewicz O, Rajput AH, Di Paolo T (2009) Metabotropic glutamate receptor II in the brains of Parkinsonian patients J Neuropath Exp Neurol, 68: 374-382
| Article (PDF) | - Pifl C, Wolf A, Rebernik P, Reither H, Berger M L (2009) Zinc regulates the dopamine transporter in a membrane potential and chloride dependent manner Neuropharmacology, 56: 531-540
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2009 Reviews
- Olsen RW, Sieghart W (2009) Subtypes provide diversity of function and pharmacology Neuropharmacology, 56: 141-148
2008 Original Articles
- Mulder J, Aguado T, Keimpema E, Barabás K, Ballester Rosado C, Nguyen L, Monory K, Marsicano G, Di Marzo V, Hurd Y, Guillemot F, Mackie K, Lutz B, Guzmán M, Lu H, Galve-Roperh I, Harkany T (2008) Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning Proc Natl Acad Sci USA, 105 (25): 8760-8765
- Savic MM, Clayton T, Furtmüller R, Gavrilovic I, Samardzic J, Savic S, Huck S, Sieghart W, Cook JM (2008) PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA-A receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats Brain Res, 1208: 150-159
| Article (PDF) | - Han D, Försterling FH, Li X, Deschamps JR, Parrish D, Cao H, Rallapalli S, Clayton T, Teng Y, Majumder S, Sankar S, Roth BL, Sieghart W, Furtmüller R, Rowlett J, Weed MR, Cook JM (2008) A study of the structure-activity relationship of GABA-A-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis Bioorg Med Chem, 16: 8853-8862
| Article (PDF) | - Choi DS, Wei W, Deitchman JK, Kharazia VN, Lesscher HMB, McMahon T, Wang D, Qi ZH, Sieghart W, Zhang C, Shokat KM, Mody I, Messing RO (2008) Protein kinase C-delta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current J Neurosci, 28: 11890-11899
- Baburin I, Khom S, Timin E, Hohaus A, Sieghart W, Hering S (2008) Estimating the efficiency of benzodiazepines on GABA-A receptors comprising gamma1 or gamma2 subunits Br J Pharmacol, 155: 424-433
- Kang SU, Fuchs K, Sieghart W, Lubec G (2008) Gel-based mass spectrometric analysis of recombinant GABA-A receptor subunits representing strongly hydrophobic transmembrane proteins J Proteome Res, 7: 3498-3506
| Article (PDF) | - Furtmüller R, Furtmüller B, Ramerstorfer J, Paladini AC, Wasowski C, Marder M, Huck S, Sieghart W (2008) 6,3'-Dinitroflavone is a low efficacy modulator of GABA(A) receptors Eur J Pharmacol, 591: 142-146
| Article (PDF) | - Harris D, Clayton T, Cook J, Sahbaie P, Halliwell RF, Furtmüller R, Huck S, Sieghart W, and DeLorey TM (2008) Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit J Med Chem, 51: 3788-3803
| Article (PDF) | - Kish SJ, Tong J, Hornykiewicz O, Rajput A, Chang LJ, Guttman M, Furukawa Y (2008) Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease Brain, 131: 120-131
| Article (PDF) | - Terunuma M, Xu J, Vithlani M, Sieghart W, Kittler J, Pangalos M, Haydon PG, Coulter DA, Moss SJ (2008) Deficits in phosphorylation of GABA-A receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus J Neurosci, 28: 376-384
| Article (PDF) | - Payne HL, Ives JH, Sieghart W, Thompson CL (2008) AMPA and kainate receptors mediate mutually exclusive effects on GABA-A receptor expression in cultured mouse cerebellar granule neurons J Neurochem, 104: 173-186
| Article (PDF) | - Savic MM, Huang S, Furtmüller R, Clayton T, Huck S, Obradovic DI, Ugresic ND, Sieghart W, Bokonjic DR, Cook JM (2008) Are GABA(A) Receptors Containing alpha5 Subunits Contributing to the Sedative Properties of Benzodiazepine Site Agonists? Neuropsychopharm, 33: 332-339
| Article (PDF) | - Zolle IM, Berger ML, Hammerschmidt F, Hahner S, Schirbel A, Peric-Simov B (2008) New Selective Inhibitors of Steroid 11ß-Hydroxylation in the Adrenal Cortex. Synthesis and Structure–Activity Relationship of Potent Etomidate Analogues J Med Chem, 51: 2244-2253
| Article (PDF) | - Rajput A.H., Sitte H.H., Rajput A., Fenton M.E., Pifl C., Hornykiewicz O. (2008) Globus pallidus dopamine and Parkinson motor subtypes. Neurology, 70: 1403-1410
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2008 Reviews
- Harkany T, Keimpema E, Barabás K, Mulder J (2008) Endocannabinoid functions controlling neuronal specification during brain development Mol Cell Endocrinol, 286 (1-2): S84-S90
- Olsen RW, Sieghart W (2008) International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit composition, pharmacology and function - update Pharmacol Rev, 60: 243-260
| Article (PDF) | - Sarto-Jackson I, Sieghart W (2008) Assembly of GABA-A receptors Mol Membr Biol, 25: 302-310
| Article (PDF) |
2008 Book Chapters
- Nanoff C, Pifl C (2008) Neurotransmitter transporters. In: , Encyclopedia of Molecular Pharmacology Springer Berlin Heidelberg: 836-842
2007 Original Articles
- Tong J, Hornykiewicz O, Furukawa Y, Kish SJ (2007) Marked dissociation between high noradrenaline vs. low noradrenaline transporter levels in human nucleus accumbens J Neurochem, 102: 1691-1702
- Schosser A, Fuchs K, Scharl T, Leisch F, Bailer U, Kasper S, Sieghart W, Hornik K, Aschauer HN (2007) Additional support for linkage of schizophrenia and bipolar disorder to chromosome 3q29 Eur Neuropsychopharmacol, 17: 501-505
| Article (PDF) | - Tan KR, Gonthier A, Baur R, Ernst M, Goeldner M, Sigel E (2007) Proximity-Accelerated chemical coupling reaction in the benzodiazepine-binding site of gamma-aminobutyric acid type A receptors: superposition of different allosteric modulators J Biol Chem, 282: 26316-26325
- Payne HL, Connelly WM, Ives JH, Lehner R, Furtmüller B, Sieghart W, Tiwari P, Lucocq JM, Lees G, Thompson CL (2007) GABA-A alpha6-containing receptors are selectively compromised in cerebellar granule cells of the ataxic mouse, stargazer. J Biol Chem, 282: 29130-29143
| Article (PDF) | - Wulff P, Goetz T, Leppä E, Linden AM, Renzi M, Swinny JD, Vekovischeva OY, Sieghart W, Somogyi P, Korpi ER, Farrant M, Wisden W (2007) From synapse to behaviour: rapid modulation of defined neuronal populations through engineered GABA-A receptors Nature Neurosci, 10: 923-929
| Article (PDF) | - Pytel M, Wojtowicz T, Mercik K, Sarto-Jackson I, Sieghart W, Ikonomidou C, Mozrzymas JW (2007) 17 beta-estradiol modulates GABAergic synaptic transmission and tonic currents during development in vitro Neuropharmacology, 52: 1342-1353
| Article (PDF) | - Sarto-Jackson I, Furtmüller R, Ernst M, Huck S, Sieghart W (2007) Spontaneous cross-link of mutated alpha1 subunits during GABA-A receptor assembly J Biol Chem, 282: 4354-4363
| Article (PDF) | - Pöhler T., Schadt O., Niepel D., Rebernik P., Berger M.L., Noe C.R. (2007) New polyamine-sensitive inhibitors of the NMDA receptor: Syntheses and pharmacological evaluation. Eur J Med Chem, 42: 175-197
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2007 Reviews
- Clayton T, Chen JL, Ernst M, Richter L, Cromer BA, Morton CJ, Ng H, Kaczorowski CC, Helmstetter FJ, Furtmüller R, Ecker G, Parker MW, Sieghart W, Cook JM (2007) An updated unified pharmacophore model of the benzodiazepine binding site of gamma-aminobutyric acid(a) receptors: correlation with comparative models Current Topics in Medicinal Chemistry, 14: 2755-2775
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2007 Book Chapters
- Sieghart W (2007) Neurobiologische Grundlagen psychischer Erkrankungen. In: , Krankheit, Krankheitsursachen und -bilder Marian B, Facultas Universitätsverlag: 380-384
- Sieghart W (2007) Subunit Composition and Structure of GABA-A receptor subtypes. In: , The GABA Receptors, 3rd edition (Enna SJ, Möhler H) Humana Press Inc.
2006 Original Articles
- Tong J, Hornykiewicz O, Kish SJ (2006) Inverse relationship between brain noradrenaline level and dopamine loss in Parkinson disease: a possible neuroprotective role for noradrenaline Arch Neurol, 63: 1724-1728
- Pifl C, Hornykiewicz O (2006) Dopamine turnover is upregulated in the caudate/putamen of asymptomatic MPTP treated rhesus monkeys. Neurochem Internat, 49: 519-524
- Tong J, Hornykiewicz O, Kish SJ (2006) Identification of a noradrenaline-rich subdivision of the human nucleus accumbens J Neurochem, 96: 349-354
- Urak L, Feucht M, Fathi N, Hornik K, Fuchs K (2006) A GABRB3 promoter haplotype associated with childhood absence epilepsy impairs transcriptional activity Hum Mol Genet, 15: 2533-2541
- Payne HL, Donoghue PS, Connelly WMK, Hinterreiter S, Tiwari P, Ives JH, Hann V, Sieghart W, Lees G, Thompson CL (2006) Aberrant GABA-A receptor expression in the dentate gyrus of the epileptic mutant mouse, stargazer J Neurosci, 26: 8600-8608
| Article (PDF) | - Hanchar HJ, Chutsrinopkun P, Meera P, Supavilai P, Sieghart W, Wallner M, Olsen R (2006) Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABA-A receptors Proc Natl Acad Sci USA, 103: 8546-8551
| Article (PDF) | - Swanwick CC, Murthy NR, Mtchedlishvili Z, Sieghart W, Kapur J (2006) Development of GABAergic Synapses in Cultured Hippocampal Neurons J Comp Neurol, 495: 497-510
| Article (PDF) | - Sarto-Jackson I, Ramerstorfer J, Ernst M, Sieghart W (2006) Identification of amino acid residues important for assembly of GABA-A receptor alpha1 and gamma2 subunits J Neurochem, 96: 983-995
| Article (PDF) | - Ogris W, Lehner R, Fuchs K, Furtmüller B, Höger H, Homanics GE, Sieghart W (2006) Investigation of the abundance and subunit composition of GABA-A receptor subtypes in the cerebellum of alpha1-subunit-deficient mice J Neurochem, 96: 136-147
| Article (PDF) | - Khom S, Baburin I, Timin EN, Hohaus A, Sieghart W, Hering S (2006) Pharmacological properties of GABA-A receptors containing gamma1 subunits Mol Pharmacol, 69: 640-649
| Article (PDF) | - Berger M.L., Bitar A.Y., Waitner M.J., Rebernik P., O'Sullivan M.C. (2006) Polyamines and the NMDA receptor: modifying intrinsic activities with aromatic substituents. Bioorg Med Chem Lett, 16: 2837-2841
| Article (PDF) | - Buchstaller H.-P., Siebert C.D., Steinmetz R., Frank I., Berger M.L., Gottschlich R., Leibrock J., Krug M., Steinhilber D.,Noe C.R. (2006) Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the NMDA receptor. J Med Chem, 49: 864-871
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2006 Reviews
- Pifl C, Sperk G (2006) Current topics in brain dopamine research: a tribute to Professor Oleh Hornykiewicz Wiener Klinische Wochenschrift, 118: 563-565
- Hornykiewicz O (2006) The discovery of dopamine deficiency in the parkinsonian brain Neural Transm Suppl, 70: 9-15
2006 Book Chapters
- Sieghart W (2006) Structure, pharmacology and function of GABA-A receptor subtypes. In: , Advances in Pharmacology 54 (Enna SJ) Elsevier Inc: 231-263
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2005 Original Articles
- Reiterer S., Hemmelmann C., Rappelsberger P., Berger M.L. (2005) Characteristic functional networks in high- versus low second language speakers detected also during native language processing: An explorative EEG coherence study in 6 frequency bands Cog Brain Res, 25: 566-578
| Article (PDF) | - Pifl C, Nagy G, Berényi S, Kattinger A, Reither H, Antus S (2005) Pharmacological characterization of ecstasy synthesis byproducts with recombinant human monoamine transporters J Pharmacol Exp Ther, 314: 346-354
- Xu J, Zhong N, Wang H, Elias JE, Kim CY, Woldman I, Pifl C, Gygi SP, Geula C, Yankner BA (2005) The Parkinson's Disease Associated DJ-1 Protein is a Transcriptional Co-Activator that Protects Against Neuronal Apoptosis Hum Mol Genet, 14: 1231-1241
- Woldman I, Reither H, Kattinger A, Hornykiewicz O, Pifl C (2005) Dopamine inhibits cell growth and cell cycle by blocking ribonucleotide reductase Neuropharmacology, 48: 525-537
- Ernst M, Bruckner S, Boresch S, Sieghart W (2005) Comparative models of GABA-A receptor extracellular and transmembrane domains: important insights in pharmacology and function Mol Pharmacol, 68: 1291-1300
| Article (PDF) | - Mangan PS, Sun C, Carpenter M, Goodkin HP, Sieghart W, Kapur J (2005) Cultured hippocampal pyramidal neurons express two kinds of GABAA receptors. Mol Pharmacol, 67: 775-788
| Article (PDF) | - Bailer U, Wiesegger G, Leisch F, Fuchs K, Leitner I, Letmaier M, Konstantinidis A, Stastny J, Sieghart W, Hornik K, Mitterauer B, Kasper S, Aschauer HN (2005) No association of clock gene T3111C polymorphism and affective disorders Eur Neuropsychopharmacol, 15: 51-55
| Article (PDF) | - Cope DW, Halbsguth C, Karayannis T, Wulff P, Ferraguti F, Hoeger H, Leppä E, Linden AM, Oberto A, Ogris W, Korpi ER, Sieghart W, Somogyi P, Wisden W, Capogna M (2005) Loss of zolpidem efficacy in the hippocampus of mice with the GABAA receptor gamma2 F77I point mutation Eur J Neurosci, 21: 3002-3016
| Article (PDF) | - Reiterer S., Berger M.L., Hemmelmann C., Rappelsberger, P. (2005) Decreased EEG coherence between prefrontal electrodes: a correlate of high language proficiency? Exp Brain Res, 163: 109-113
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2005 Reviews
- Sieghart W, Ernst M (2005) Heterogeneity of GABA-A receptors: revived interest in the development of subtype-selective drugs Curr Med Chem - Centr Nervous Syst, 5: 217-242
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2004 Original Articles
- Klein N, Wiesegger G, Attarbaschi T, Winkler D, Mossaheb N, Kasper S, Tauscher J (2004) A naturalistic observational study of escitalopram in the treatment of depression and anxiety disorder in adult outpatients Rom J Psychopharma, 4: 1-9
- Mitterhauser M, Wadsak W, Wabnegger L, Mien L-K, Tögel S, Langer O, Sieghart W, Viernstein H, Kletter K, Dudczak R (2004) Biological evaluation of 2'-[18F]fluoroflumazenil ([18F]FFMZ), a potential GABA receptor ligand for PET Nucl Med and Biol, 31: 291-295
| Article (PDF) | - Calon F, Dridi M, Hornykiewicz O, Bédard PJ, Rajput AH, Di Paolo T (2004) Increased adenosine A2A receptors in the brain of Parkinson’s disease patients with dyskinesias. Brain, 127: 1075-1084
- Zecca L, Stroppolo A, Gatti A, Tampellini D, Toscani M, Gallorini M, Giaveri G, Arosio P, Santambrogio P, Fariello RG, Karatekin E, Kleinman MH, Turro N, Hornykiewicz O, and Zucca FA (2004) The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging. Proc Natl Acad Sci USA, 101: 9843-9848
- Rajput AH, Fenton ME , Di Paolo T, Sitte H, Pifl C Hornykiewicz O (2004) Human brain dopamine metabolism in levodopa-induced dyskinesia and wearing-off Parkinsonism & Related Disorders, 10: 221-226
- Pifl C, Khorchide M, Kattinger A, Reither H, Hardy J, Hornykiewicz O (2004) alpha-Synuclein selectively increases manganese-induced viability loss in SK-N-MC neuroblastoma cells expressing the human dopamine transporter Neurosci Lett, 354: 34-37
- Pifl C, Rebernik P, Kattinger A, Reither H (2004) Zn2+ modulates currents generated by the dopamine transporter: parallel effects on amphetamine-induced charge transfer and release Neuropharmacology, 46: 223-231
| Article (PDF) | - Schosser A, Fuchs K, Leisch F, Bailer U, Meszaros K, Lenzinger E, Willinger U, Strobl R, Heiden A, Gebhardt C, Kasper S, Sieghart W, Hornik K, Aschauer HN (2004) Possible linkage of schizophrenia and bipolar affective disorders to chromosome 3q29; a follow-up. J Psychiatr Res, 38: 357-364
- Cope DW, Wulff P, Oberto A, Aller MI, Capogna M, Ferraguti F, Halbsguth C, Höger H, Jolin HE, Jones A, Mckenzie ANJ, Ogris W, Pöltl A, Sinkkonen ST, Vekovischeva OY, Korpi ER, Sieghart W, et al (2004) Abolition of zolpidem sensitivity in mice with a point mutation in the GABAA receptor gamma2 subunit Neuropharmacology, 47: 17-34
| Article (PDF) | - Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H,Wisden W, Sieghart W (2004) Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABAA receptor gamma2 subunit Biochem Pharmacol, 68: 1621-1629
| Article (PDF) | - Petrini EM, Marchionni I, Zacchi P, Sieghart W, Cherubini E (2004) Clustering of extrasynaptic GABAA receptors modulates tonic inhibition in cultured hippocampal neurons J Biol Chem, 279: 45833-45843
| Article (PDF) | - Sinkkonen ST, Vekovischeva OY, Möykkynen T, Ogris W, Sieghart W, Wisden W, Korpi E (2004) Behavioral correlates of an altered balance between synaptic and extrasynaptic GABAAergic inhibition in a mouse model Eur J Neurosci, 20: 2168-2178
| Article (PDF) | - Sun C, Sieghart W, Kapur J (2004) Distribution of alpha1, alpha4, gamma2 and delta subunits of GABA A receptors in hippocampal granule cells Brain Res, 1029: 207-216
| Article (PDF) | - Schirbel A., Zolle I., Hammerschmidt F., Berger M.L., Schiller D., Kvaternik H., Reiners C. (2004) [123/131I]Iodometomidate as a radioligand for functional diagnosis of adrenal disease: synthesis, structural requirements and biodistribution. Radiochim Acta, 92: 297-303
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2004 Reviews
- Olanow CW, Agid Y, Mizuno Y, Albanese A, Bonucelli U, Damier P, de Yebenes J, Gershanik O, Guttman M, Grandas F, Hallett M, Hornykiewicz O, Jenner P, Katzenschlager R, Langston WJ, LeWitt P, Melamed E (2004) Levodopa in the treatment of Parkinson’s disease: current controversies Movement Disorders, 19: 997-1005
- Yamamoto K, Hornykiewicz O (2004) Proposal for a noradrenaline hypothesis of schizophrenia. Progr Neuro-Psychopharmacol & Biol Psychiat, 28: 913-922
2004 Book Chapters
- Sieghart W (2004) Laboruntersuchungen in der Psychiatrie. In: , Psychische Funktionen in Gesundheit und Krankheit Springer-Kremser M, Löffler-Stastka H, Facultas Universitätsverlag: 374-381
2003 Original Articles
- Ehya N, Sarto I, Wabnegger L, Klausberger T, and Sieghart W (2003) Identification of an amino acid sequence within GABAA receptor beta3 subunits that is important for receptor assembly J Neurochem, 84: 127-135
- Ernst M, Brauchart D, Boresch S, and Sieghart W (2003) Comparative modeling of GABAA receptors: limits, insights, future developments Neuroscience, 119: 933-943
- Mitterhauser M, Wadsak W, Wabnegger L, Sieghart W, Viernstein H, Kletter K, Dudczak R (2003) In vivo and in vitro evaluation of [18F]FETO with respect to the adrenocortical and GABAergic system in rats Eur J Nucl Med Mol Imaging, 30: 1398-1401
- Pirker S, Schwarzer C, T. Czech T, Baumgartner C, Pockberger H, Maier H, Hauer B, Sieghart W, Furtinger S, and Sperk G (2003) Increased expression of GABAA receptor beta-subunits in the hippocampus of patients with temporal lobe epilepsy J Neuropath Exp Neurol, 62: 820-834
- Willeit M, Praschak-Rieder N, Neumeister A, Zill P, Leisch F, Stastny J, Hilger E, Thierry N, Konstantinidis A, Winkler D, Fuchs K , Sieghart W, Aschauer H, Ackenheil M, et al (2003) A polymorphism (5-HTTLPR) in the serotonin transporter promoter gene is associated with DSM-IV depression subtypes in seasonal affective disorder Mol Psychiatry, 8: 942-946
- Pöltl A, Hauer B, Fuchs K, Tretter V, Sieghart W (2003) Subunit composition and quantitative importance of GABAA receptor subtypes in the cerebellum of mouse and rat. J Neurochem, 87: 1444-1455
- Li X, Cao H, Zhang C, Furtmüller R, Fuchs K, Huck S, Sieghart W, Deschamps J, Cook JM (2003) Synthesis, in vitro affinity, and efficacy of a bis 8-ethynyl-4H-imidazol[1,5a]- [1,4]benzo-diazepine analogue, the first bivalent alpha5 subtype selective BzR/GABAA antagonist J Med Chem, 46: 5567-5570
2003 Book Chapters
- Sieghart W (2003) Benzodiazepines, benzodiazepine receptors, and endogenous ligands. In: Boer, J.A., Ad Sitsen, J.M, Handbook of Depression and Anxiety eds. Marcel Dekker, Inc. New York, Basel: 415-442
- Berger, M.L., Noe, C.R. (2003) Polyamine regulation of the NMDA receptor complex as a target in drug development. In: Ramchandran, U., Current Topics in Medicinal Chemistry Research Trends, Trivandrum: 51-64
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2002 Original Articles
- Sarto I, Wabnegger L, Dögl E, Sieghart W (2002) Homologous sites of GABA-A receptor alpha1, beta3 and gamma2 subunits are important for assembly Neuropharmacology, 43: 482-491
- Wisden W, Cope D, Klausberger T, Hauer B, Sinkkonen S T, Tretter V, Lujan R, Jones A, Korpi E R, Mody I, Sieghart W, Somogyi P, (2002) Ectopic expression of the GABA-A receptor alpha 6 subunit in hippocampal pyramidal neurons produces extrasynaptic receptors and an increased tonic inhibition. Neuropharmacology, 43: 530-549
- Kumar S, Sieghart W, Morrow AL (2002) Association of protein kinase C with GABA-A receptors containing alpha1 and alpha4 subunits in the cerebral cortex: selective effects of chronic ethanol consumption J Neurochem, 82: 110-117
- Bailer U, Leisch F, Meszaros K, Lenzinger E, Willinger U, Strobl R, Heiden A, Gebhardt C, Dögl E, Fuchs K, Sieghart W, Kasper S, Hornik K, Aschauer HN (2002) Genome scan for susceptibility loci for schizophrenia and bipolar disorder Biol Psychiatry, 52: 40-52
- Sarto I, Klausberger T, Ehya N, Mayer B, Fuchs K, Sieghart W (2002) A novel site on gamma3 subunits important for assembly of GABA-A receptors J Biol Chem, 277: 30656-30664
- El Hadri A, Abouabdellah A, Thomet U, Baur R, Furtmüller R, Sigel E, Sieghart W, Dodd RH (2002) N-Substituted 4-amino-3,3-dipropyl-2(3H)-furanones: new positive allosteric modulators of the GABA-A receptor sharing electrophysiological properties with the anticonvulsant loreclezole J Med Chem, 45: 2824-2831
- Peng Z, Hauer B, Mihalek RM, Homanics GE, Sieghart W, Olsen RW, Houser CR (2002) GABA-A receptor changes in delta subunit-deficient mice: altered expression of alpha4 and gamma2 subunits in the forebrain J Comp Neurol, 446: 179-197
- Korpi ER, Mihalek RM, Sinkkonen ST, Hauer B, Hevers W, Homanics GE, Sieghart W, Lüddens H (2002) Altered receptor subtypes in the forebrain of GABA-A receptor delta subunit-deficient mice: recruitment of gamma2 subunits Neuroscience, 109: 733-743
- Furtmüller R, Schlag MG, Berger M L, Hopf R, Huck S, Sieghart W, Redl H (2002) Tranexamic acid, a widely used antifibrinolytic agent, causes convulsions by a gamma-aminobutyric acid-A-receptor antagonistic effect J Pharmacol Exp Ther, 301: 168-173
- Pifl C, Kattinger A, Reither H, Hornykiewicz O (2002) Cellular effects of dopamine - beyond oxidative mechanisms Parkinsonism & Related Disorders, 8: 433-437
- Kristufek D, Rudorfer W, Pifl C, Huck S (2002) Organic cation transporter mRNA and function in the rat superior cervical ganglion J Physiol, 543: 117-134
2002 Reviews
- Sieghart, W and Sperk, G (2002) Subunit composition, distribution and function of GABA-A receptor subtypes Current Topics in Medicinal Chemistry, 2: 795-816
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2002 Book Chapters
- Pifl C, Caron MG (2002) The dopamine transporter: molecular biology, pharmacology and genetics. In: , Handbook of Experimental Pharmacology Springer Berlin Heidelberg New York: 257-297
2001 Original Articles
- Saha S, Sieghart W, Fritschy JM, McWilliam PN, Batten TF (2001) gamma-aminobutyric acid receptor (GABA-A) subunits in rat nucleus tractus solitarii (NTS) revealed by polymerase chain reaction (PCR) and immunohistochemistry Mol Cell Neurosci, 17: 241-257
- Buhr A, Wagner C, Fuchs K, Sieghart W, Sigel E (2001) Two novel residues in M2 of the GABA-A receptor affecting gating by GABA and picrotoxin affinity J Biol Chem, 276: 7775-7781
- Maric D, Liu QY, Maric I, Chaudry S, Chang YH, Smith SV, Sieghart W, Fritschy JM, Barker JL (2001) GABA expression dominates neuronal lineage progression in the embryonic rat neocortex and facilitates neurite outgrowth via GABA-A autoreceptor/Cl-channels J Neurosci, 21: 2343-2360
- Sigel E, Baur R, Furtmüller R, Razet R, Dodd RH, Sieghart W (2001) Differential cross talk of ROD compounds with the benzodiazepine binding site Mol Pharmacol, 59: 1470-1477
- Schwarzer C, Berresheim U, Pirker S, Wieselthaler A, Fuchs K, Sieghart W, Sperk G (2001) Distribution of the major gamma-aminobutyric acid(A) receptor subunits in the basal ganglia and associated limbic brain areas of the adult rat J Comp Neurol, 433: 526-549
- Klausberger T, Ehya N, Fuchs K, Fuchs T, Ebert V, Sarto I, Sieghart W (2001) Detection and binding properties of GABA-A receptor assembly intermediates J Biol Chem, 276: 16024-16032
- Tretter V, Hauer B, Nusser Z, Mihalek RM, Höger H, Homanics GE, Somogyi P, Sieghart W (2001) Targeted disruption of the GABA(A) receptor delta subunit gene leads to an upregulation of gamma 2 subunit containing receptors in cerebellar granule cells J Biol Chem, 276: 10532-10538
- Sitte H.H., Wanschitz J., Budka H., Berger M.L. (2001) Autoradiography with [3H]PK11195 of spinal tract degeneration in amyotrophic lateral sclerosis Acta Neuropathol, 101: 75-78
| Article (PDF) | - Dellovade TL, Davis AM, Ferguson C, Sieghart W, Homanics GE, Tobet SA (2001) GABA influences the development of the ventromedial nucleus of the hypothalamus J Neurobiol, 49: 264-276
- Klausberger T, Sarto I, Ehya N, Fuchs K, Furtmüller R, Mayer B, Huck S, Sieghart W (2001) Alternate use of distinct intersubunit contacts controls GABA-A receptor assembly and stoichiometry J Neurosci, 21: 9124-9133
- Willeit M, Stastny J, Pirker W, Praschak-Rieder N, Neumeister A, Asenbaum S, Tauscher J, Fuchs K, Sieghart W, Hornik K, Aschauer HN, Brücke T, Kasper S (2001) No evidence for in vivo regulation of midbrain serotonin transporter availability by serotonin transporter promoter gene polymorphism Biol Psychiatry, 50: 8-12
- Sitte HH, Hiptmair B, Zwach J, Pifl C, Singer EA, Scholze P (2001) Quantitative analysis of inward and outward transport rates in cells stably expressing the cloned human serotonin transporter: inconsistencies with the hypothesis of facilitated exchange diffusion Mol Pharmacol, 59: 1129-1137
| Article (PDF) | - Pifl C, Zezula J, Spittler A, Kattinger A, Reither H, Caron MG, Hornykiewicz O (2001) Antiproliferative action of dopamine and norepinephrine in neuroblastoma cells expressing the human dopamine transporter FASEB J, 15: 1607-1609
- Krapfenbauer K., Berger M.L., Lubec G., Fountoulakis M. (2001) Changes in the levels of low-abundance brain proteins induced by kainic acid. Eur J Biochem, 268: 3532-3537
- Krapfenbauer K., Berger M.L., Lubec G., Fountoulakis M. (2001) Changes in the brain protein levels following administration of kainic acid. Electrophoresis, 22: 2086-2091
2000 Original Articles
- Pifl C, Sitte HH, Reither H, Singer EA (2000) The mechanism of the releasing action of amphetamine. Uptake, superfusion and electrophysiological studies on transporter-transfected cells Pure Appl Chem, 72: 1045-1050
- Razet R, Thomet U, Furtmüller R, Chiaroni A, Sigel E, Sieghart W, Dodd RH (2000) 5-{1´-(2´,3´,4´-tetrahydroisoquinolyl)}-4,5-dihydro-2(3H)-furanones: positive allosteric modulators of the GABA-A receptor with a new mode of acion J Med Chem, 43: 4363-4366
- Bailer U, Leisch F, Meszaros K, Lenzinger E, Willinger U, Strobl R, Gebhardt C, Gerhard E, Fuchs K, Sieghart W, Kasper S, Hornik K, Aschauer HN on behalf of the European Science Foundation Programme (2000) Genome scan for Susceptibility Loci for Schizophrenia Neuropsychobiology, 42: 175-182
- Meszaros K, Lenzinger E, Hornik K, Füreder T, Stompe T, Willinger U, Heiden A, Fathi N, Gerhard E, Fuchs K, Sieghart W, Kasper S, Aschauer HN (2000) Association study of schizophrenia spectrum disorders and dopamine D3 receptor gene: is schizoaffective disorder special? Psychiat Res, 96: 179-183
- Razet R, Thomet U, Furtmüller R, Jursky F, Sigel E, Sieghart W, Dodd RH (2000) Use of bicuculline, a GABA antagonist, as a template for the development of a new class of ligands showing positive allosteric modulation of the GABA-A receptor Bioorg Med Chem Lett, 10: 2579-2583
- Do-Rego JL, Mensah-Nyagan GA, Beaujean D, Vaudry D, Sieghart W, Luu-The V, Pelletier G, Vaudry H (2000) gamma-Aminobutyric acid, acting through gamma-aminobutyric acid type A receptors, inhibits the biosynthesis of neurosteroids in the frog hypothalamus PNAS, 97: 13925-13930
- Simonian SX, Skynner MJ, Sieghart W, Essrich C, Lüscher B, Herbison AE (2000) Role of the GABA-A receptor gamma2 subunit in the development of gonadotropin-releasing hormone neurons in vivo Eur J Neurosci, 12: 3488-3496
- Thomet U, Baur R, Razet R, Dodd RH, Furtmüller R, Sieghart W, Sigel E (2000) A novel positive allosteric modulator of the GABA-A receptor: the action of (+)-ROD188 Br J Pharmacol, 131: 843-850
- Brandon NJ, Delmas P, Kittler JT, McDonald BJ, Sieghart W, Brown DA, Smart TG, Moss SJ (2000) GABA-A receptor phosphorylation and functional modulation in cortical neurons by a protein kinase C-dependent pathway J Biol Chem, 275: 38856-38862
- Uusi-Oukari M, Heikkila J, Sinkkonen ST, Makelä R, Hauer B, Homanics GE, Sieghart W, Wisden W, Korpi ER (2000) Long-range interactions in neuronal gene expression: evidence from gene targeting in the GABA-A receptor beta2-alpha6-alpha1-gamma2 subunit gene cluster Mol Cell Neurosci, 16: 34-41
- Nicoletti D, Ghini AA, Furtmüller R, Sieghart W, Dodd RH, Burton G (2000) Synthesis and GABA-A receptor activity of 6-oxa-analogs of neurosteroids Steroids, 65: 349-356
- Sassoe-Pognetto M, Panzanelli P, Sieghart W, Fritschy JM (2000) Colocalization of multiple GABA-A receptor subtypes with gephyrin at postsynaptic sites J Comp Neurol, 420: 481-498
- Klausberger T, Fuchs K, Mayer B, Ehya N, Sieghart W (2000) GABA-A receptor assembly: Identification and structure of gamma2 sequences forming the intersubunit contacts with alpha1 and beta3 subunits J Biol Chem, 275: 8921-8928
- Louiset E, McKernan R, Sieghart W, Vaudry H (2000) Subunit composition and pharmacological characterization of gamma-aminobutyric acid type A receptors in frog pituitary melanotrophs Endocrinology, 141: 1083-1092
- Okada M, Onodera K, Van Reterghem C, Sieghart W, Takahashi T (2000) Functional correlation of GABA-A receptor a subunits expression with the properties of IPSCs in the developing thalamus J Neurosci, 20: 2202-2208
- Gebhardt C, Leisch F, Schüssler P, Fuchs K, Stompe T, Sieghart W, Hornik K, Kasper S, Aschauer HN (2000) Non-association of dopamine D4 and D2 receptor genes with personality in healthy individuals Psychiat Gen, 10: 131-137
- Pirker S, Schwarzer C, Wieselthaler A, Sieghart W, Sperk G (2000) GABA-A receptors: immunocytochemical distribution of 13 subunits in the adult rat brain Neuroscience, 101: 815-850
- Heiden A, Schüssler P, Itzlinger U, Leisch F, Scharfetter J, Gebhardt C, Fuchs K, Willeit M, Nilsson L, Miller-Reiter E, Meszaros K, Sieghart W, Hornik K, Kasper S, Aschauer HN (2000) Association studies of candidate genes in bipolar disorders Neuropsychobiology, 42: 18-21
- Jursky F, Fuchs K, Buhr A, Tretter V, Sigel E, Sieghart W (2000) Identification of aminoacid residues of GABA(A) receptor subunits contributing to the formation and affinity of the tert-butylbicyclophosphorothionate binding site J Neurochem, 74: 1310-1316
- Sitte HH, Scholze P, Schloss P, Pifl C, Singer EA (2000) Characterization of carrier-mediated efflux in human embryonic kidney 293 cells stably expressing the rat serotonin transporter: a superfusion study J Neurochem, 74: 1317-1324
- Scholze P, Zwach J, Kattinger A, Pifl V, Singer EA, Sitte HH (2000) Transporter-mediated release: a superfusion study on human embryonic kidney cells stably expressing the human serotonin transporter J Pharmacol Exp Ther, 293: 870-878p
- Berger M L (2000) Tryptamine derivatives as non-competitive N-methyl-D-aspartate receptor blockers: studies using [3H]MK-801 binding in rat hippocampal membranes Neurosci Lett, 296: 29-33
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2000 Reviews
- Sieghart W (2000) Unraveling the function of GABA-A receptor subtypes Trends Pharmacol Sci, 21: 411-413
1999 Original Articles
- Scharfetter J, Chaudhry HR, Hornik K, Fuchs K, Sieghart W, Kasper S, Aschauer HN (1999) Dopamine D3 receptor gene polymorphism and response to clozapine in schizophrenic Pakistani patients Eur Neuropsychopharmacol, 10: 17-20
- Kapitany T, Schindl M, Schindler SD, Heßelmann B, Füreder T, Barnas C, Sieghart W, Kasper S (1999) The citalopram challenge test in patients with major depression and in healthy controls Psychiat Res, 88: 75-88
- Nusser Z, Sieghart W, Mody I (1999) Differential regulation of synaptic GABA-A receptors by cAMP-dependent protein kinase in mouse cerebellar and olfactory bulb neurons J Physiol, 521: 421-435
- Feucht M, Fuchs K, Pichlbauer E, Hornik K, Scharfetter J, Goessler R, Füreder T, Cvetkovic N, Sieghart W, Kasper S, Aschauer H (1999) Possible association between childhood absence epilepsy and the gene encoding GABRB3 Biol Psychiatry, 46: 997-1002
- Gustincich S, Feigenspan A, Sieghart W, Raviola E (1999) Composition of the GABA-A receptors of retinal dopaminergic neurons J Neurosci, 19: 7812-7822
- Thomet U, Furtmüller R, Sieghart W, Le Hyaric-Almeida M, Rousseau JF, Dodd RH, Venault P, Chapouthier G, Sigel E (1999) EDPC: a novel high affinity ligand for the benzodiazepine site on rat GABA-A receptors Neurosci Lett, 269: 63-66
- Levi S, Chesnoy-Marchais D, Sieghart W, Triller A (1999) Synaptic control of glycine-, GABA-A receptors and gephyrin expression in cultured motoneurons J Neurosci, 19: 7434-7449
- Kannenberg K, Schaerer MT, Fuchs K, Sieghart W, Sigel E (1999) A novel serine kinase with specificity for beta3 subunits is tightly associated with GABA-A receptors J Biol Chem, 274: 21257-21264
- Thomet U, Baur R, Scholze P, Sieghart W, Sigel E (1999) Dual mode of stimulation by the beta-carboline ZK91085 of recombinant GABA-A receptor currents: molecular determinants affecting its action Br J Pharmacol, 127: 1231-1239
- Chen S, Huang Z, Zeng XJ, Sieghart W, Tietz EI (1999) Benzodiazepine-mediated regulation of alpha1, alpha2, beta1-3 and gamma2 GABA-A receptor subunit proteins in the rat brain hippocampus and cortex Neuroscience, 93: 33-44
- Maric D, Maric I, Wen X, Fritschy JM, Sieghart W, Barker JL, Serafini R (1999) GABA-A receptor subunit and composition and functional properties of Cl-channels with differential sensitivity to zolpidem in embryonic rat hippocampal cells J Neurosci, 19: 4921-4937
- Lenzinger E, Neumeister A, Praschak-Rieder N, Fuchs K, Gerhard E, Willeit M, Sieghart W, Kasper SF, Hornik K, Aschauer HN (1999) Behavioral effects of tryptophan depletion in seasonal affective disorder associated with the serotonin transporter gene? Psychiat Res, 22: 241-246
- Ebert V, Scholze P, Fuchs K, Sieghart W (1999) Identification of subunits mediating clustering of GABA-A receptors by rapsyn Neurochem Internat, 34: 453-463
- Kannenberg K, Sieghart W, Reuter H (1999) Clusters of GABA-A receptors on cultured hippocampal cells correlate only partially with functional synapses Eur J Neurosci, 11: 1256-1264
- Tobet SA, Henderson RG, Whiting PJ, Sieghart W (1999) Special relationship of gamma-aminobutyric acid to the ventromedial nucleus of the hypothalamus during embryonic development J Comp Neurol, 405: 88-98
- Bencits E, Ebert V, Tretter V, Sieghart W, (1999) A significant part of native gamma-aminobutyric acid-A receptors containing alpha4 do not contain gamma or delta subunits J Biol Chem, 274: 19613-19616
- Nusser Z, Ahmad Z, Tretter V, Fuchs K, Wisden W, Sieghart W, Somogyi P (1999) Alterations in the expression of GABA-A receptor subunits in cerebellar granule cells after the disruption of the alpha6 subunit gene Eur J Neurosci, 11: 1685-1697
- Mihalek RM, Banerjee PK, Korpi ER, Quinlan JJ, Firestone LL, Mi Z, Lagenaur C, Tretter V, Sieghart W, Anagnostaras SG, Sage JR, Fanselow MS, Guidotti A, DeLorey TM, Olsen RW, Homanics GE (1999) Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice PNAS, 96: 12905-12910
- Pifl C, Agneter E, Drobny H, Sitte HH, Singer EA (1999) Amphetamine reverses or blocks the operation of the human noradrenaline transporter depending on its concentration: superfusion studies on transfected cells Neuropharmacology, 38: 157-165
- Pifl C, Singer EA (1999) Ion dependence of carrier-mediated release in dopamine or norepinephrine transporter-transfected cells questions the hypothesis of faciliated exchange diffusion Mol Pharmacol, 56: 1047-1054
- Furukawa Y, Nygaard TG, Gutlich M, Rajput AH, Pifl C, DiStefano L, Chang LJ, Price K, Shimadzu M, Hornykiewicz O, Haycock JW, Kish SJ (1999) Striatal biopterin and tyrosine hydroxylase protein reduction in dopa-responsive dystonia Neurology, 53: 1032-1041
- Berger M L, Rebernik P (1999) Zinc and Ifenprodil Allosterically Inhibit Two Separate Polyamine-Sensitive Sites at N-Methyl-D-Aspartate Receptor Complex J Pharmacol Exp Ther, 289: 1584-1591
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1999 Reviews
- Sieghart W, Fuchs K, Tretter V, Eber V, Jechlinger M, Höger H, Adamiker D (1999) Structure and subunit composition of GABA-A receptors Neurochem Internat, 34: 379-385
1998 Original Articles
- Kapitany T, Meszaros K, Lenzinger E, Schindler SD, Barnas C, Fuchs K, Sieghart W, Aschauer HN, Kasper S (1998) Genetic polymorphisms for drug metabolism (CYP2D6) and tardive dyskinesia in schizophrenia Schizophr Res, 32: 101-106
- Serafini R, Ma W, Maric D, Maric I, Lahjouji F, Sieghart W, Barker JL (1998) Initially expressed early embryonic GABA-A receptor Cl- ion channels exhibit heterogeneous channel properties Eur J Neurosci, 10: 1771-1783
- Mitsuyama H, Little KY, Sieghart W, Devaud LL, Morrow AL (1998) GABA-A receptor alpha1, alpha4 and beta3 subunit mRNA and protein expression in the frontal cortex of human alcoholics Alcohol Clin Exp Res, 22: 815-822
- Spurlock G, Williams J, McGuffin P, Aschauer HN, Lenzinger E, Fuchs K, Sieghart W, Meszaros K, Fathi N, Laurent C, Mallet J, Macciardi F, Pedrini S, Gill M, Hawi Z, Gibson S, Adolfsson R, Owen MJ (1998) European Multicentre Association Study of Schizophrenia: A study of the DRD2Ser311Cys and DRD3Ser9Gly Polymorphisms Am J Med Genet, 81: 24-28
- Matthews DB, Devaud LL, Fritschy JM, Sieghart W, Morrow AL (1998) Differential regulation of GABA-A receptor gene expression by ethanol in the rat hippocampus versus cerebral cortex J Neurochem, 70: 1160-1166
- Nusser Z, Sieghart W, Somogyi P (1998) Segregation of different GABA-A receptors to synaptic and extrasynaptic membranes of cerebellar granule cells J Neurosci, 18: 1693-1703
- Sitte HH, Huck S, Reither H, Boehm S, Singer EA, Pifl C (1998) Carrier-mediated release, transport rates and charge transfer induced by amphetamine, tyramine and dopamine in mammalian cells transfected with the human dopamine transporter J Neurochem, 71: 1289-1297
- Berger M.L, Schödl C, Noe CR (1998) Inverse agonists at the polyamine-sensitive modulatory site of the NMDA receptor: 50-fold increase in potency by insertion of an aromatic ring into an alkanediamine chain Eur J Med Chem, 33: 3-14
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1998 Reviews
- Barnard EA, Skolnick P, Olsen RW, Möhler H, Sieghart W, Biggio G, Braestrup C, Bateson AN, Langer SZ (1998) International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acid-A receptors: classification on the basis of subunit structure and receptor function Pharmacol Rev, 50: 291-313
1997 Original Articles
- Maric D, Maric I, Ma W, Lahojuji F, Somogyi R, Wen X, Sieghart W, Fritschy JM, Barker JL (1997) Anatomical gradients in proliferation and differentiation of embryonic rat CNS accessed by buoyant density fractionation: alpha3, beta3 and gamma2 GABA-A receptor subunit co-expression by postmitotic Eur J Neurosci, 9: 507-522
- Tretter V, Ehya N, Fuchs K, Sieghart W (1997) Stoichiometry and assembly of a recombinant GABA-A receptor subtype J Neurosci, 17: 2728-2737
- Jones A, Korpi ER, McKernan RM, Nusser Z, Pelz R, Mäkelä R, Mellor JR, Pollard S, Bahn S, Stephenson RA, Randall AD, Sieghart W, Somogyi P, Smith AJH, Wisden W (1997) Ligand-gated ion channel subunit partnerships: GABA-A receptor alpha6 subunit gene inactivation inhibits delta subunit expression J Neurosci, 17: 1350-1362
- Pifl C, Agneter E, Drobny H, Reither H, Singer EA (1997) Induction by low Na+ or Cl- of cocaine sensitive carrier-mediated efflux of amines from cells transfected with the cloned human catecholamine transporters Br J Pharmacol, 121: 205-212
1996 Original Articles
- Meszaros K, Lenzinger E, Füreder T, Hornik K, Willinger U, Stompe T, Heiden AH, Resinger E, Fathi N, Gerhard E, Fuchs K, Miller-Reiter E, Pfersmann V, Sieghart W, Aschauer HN, Kasper S (1996) Schizophrenia and the dopamine-beta-hydroxylase gene: results of a linkage and association study Psychiat Gen, 6: 17-22
1995 Original Articles
- Berger M L (1995) On the true affinity of glycine for its binding site at the NMDA receptor complex J Pharmacol Tox Meth, 34: 79-88
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1993 Original Articles
- Sieghart W, Item C, Buchstaller A, Fuchs K, Höger H, Adamiker D (1993) Evidence for the existence of differential O-glycosylated alpha5-subunits of the gamma-aminobutyric acid-A receptor in the rat brain J Neurochem, 60: 93-98
1993 Book Chapters
- Ruhrmann S, Kasper S, Danos P, Höflich G, Möller HJ (1993) Angst bei saisonal-abhängiger Depression (SAD) und Lichttherapie. In: Baumann P (Hrsg.), Biologische Psychiatrie der Gegenwart Wien, New York, Springer : pp. 264-267
1992 Book Chapters
- Kasper S (1992) Antidepressant medication and therapeutic sleep deprivation in depressed patients. In: Macher J.P., Crocq M.A. (Hrsg), New prospects in psychiatry, The bio-clinical interface I, Developments in psychiatry Amsterdam, London, New York, Tokyo, Elsevier : pp. 215-222
