Research Labs

The research questions target not only rare peroxisomal disorders such as X-linked adrenoleukodystrophy but also the role of peroxisomes in common neurodevelopmental and neurodegenerative disorders.

We study GABA-A receptor structure, function and pharmacology – project deal with e.g. the identification of novel binding sites, optimization of ligand selectivity, functional characterization of variants, or structure prediction.

We study the neurotransmitter receptors for GABA and Acetylcholine aiming to understand, which receptor subtypes actually exist, where they are distributed in the brain, and how they can be modulated pharmacologically.

Lipids are fascinating molecules and integral to forming the core structure of brain tissue. Our research explores how specific lipids influence innate immunity and the reactivity of various brain cell types, aiming to uncover how dysfunction in lipid metabolism could contribute to neurodegeneration and neuroinflammation.