Research Labs

Peroxisomes are lipid-metabolizing organelles, and deficiency in the associated pathways result in severe damage to the nervous system. In particular we are focussing on the very-long chain fatty acid degradation by the peroxisomal ß-oxidation deficient in X-linked Adrenoleukodystrophy and ether-lipid deficiency also associated to common neuro-developmental and neurodegenerative disorders. We also explores the molecular mechanisms underlying peroxisomal protein import.

The Ernst lab interest is at the interface between structure-based medicinal chemistry, neuropharmacology and neuropathophysiology with projects dealing with selected GABA_A receptor subunits and subtypes.

The Scholze lab works on many aspects of normal an aberrant biochemistry, pharmacology and physiology of neuronal nicotinic acetylcholine receptors and GABA_A receptors.

Lipids are fascinating molecules and integral to forming the core structure of brain tissue. Our research explores how specific lipids influence innate immunity and the reactivity of various brain cell types, aiming to uncover how dysfunction in lipid metabolism could contribute to neurodegeneration and neuroinflammation.